Simple Summary Sialylation is the synthetic process of sialoglycans, which are important in
tumor transformation, proliferation, metastasis, and immune evasion. The primary subjects of …

Aberrant glycosylation is a key feature of malignant transformation. Hypersialylation, the
enhanced expression of sialic acid-terminated glycoconjugates on the cell surface, has …

Simple Summary All cells are covered in a thick layer of sugar molecules known as glycans.
Changes to this sugar coat are common in cancer, and in particular cancer cells often …

Simple Summary Tumor cells accumulate sialylation in tissues via the coordination of
sialyltransferases and sialidases. Tumor sialylation can block receptor and ligand binding at …

Simple Summary Sialylation is a post-translational modification that consists in the addition
of sialic acid to growing glycan chains on glycoproteins and glycolipids. Aberrant sialylation …

Upregulation of sialyltransferases—the enzymes responsible for the addition of sialic acid to
growing glycoconjugate chains—and the resultant hypersialylation of up to 40–60% of …

Tumorigenesis and metastasis are frequently associated with altered structure and
expression of oligosaccharides on cell surface glycoproteins and glycolipids. The …

Cell surface carbohydrates (known as glycans) are often aberrantly expressed or found at
atypical levels in cancer. Glycans can impact all steps in tumour progression, from malignant …

Simple Summary The aberrant sialylation of membrane glycocalyx plays a pivotal role in the
regulation of malignant cell behavior and correlates with a worse prognosis and shorter …

Aberrant glycosylation is a hallmark of cancer cells with increased evidence pointing to a
role in tumor progression. In particular, aberrant sialylation of glycoproteins and glycolipids …