Major histocompatibility complex (MHC) molecules are only found in jawed vertebrates and
not in more primitive species. MHC class II type structures likely represent the ancestral …

During maturation of MHC II molecules, newly synthesized and assembled complexes of
MHC II αβ dimers with invariant chain (Ii) are targeted to endosomes, where Ii is proteolyzed …

Background Classical major histocompatibility complex (MHC) class II molecules play an
essential role in presenting peptide antigens to CD4+ T lymphocytes in the acquired …

Structures of peptide-loaded major histocompatibility complex class I (pMHC-I) and class II
(pMHC-II) complexes are similar. However, whereas pMHC-II complexes include similar …

MHC molecules evolved with the descent of jawed fishes some 350–400 million years ago.
However, very little is known about the structural features of primitive MHC molecules. To …

At the cell surface, major histocompatibility complex (MHC) class I molecules present
fragments of intracellular antigens to the immune system. This is the end result of a cascade …

The present review focuses on the history of genes involved in the major histocompatibility
complex (MHC), with a special emphasis on class I function in peptide presentation. The …

Over the past year, several important advances have been made in understanding the
mechanisms by which class II MHC glycoproteins acquire endosomal peptides inside …

Abstract Background MHC class I (MHCI) molecules are the key presenters of peptides
generated through the intracellular pathway to CD8-positive T-cells. In fish, MHCI genes …

This report describes two zebrafish cDNAs each of which encodes a new, hypothetical, type
II transmembrane protein that shares homologous domains with the mammalian major …