[HTML][HTML] Effects of neohesperidin dihydrochalcone (NHDC) on oxidative phosphorylation, cytokine production, and lipid deposition

S Choi, S Yu, J Lee, W Kim - Foods, 2021 - mdpi.com
The sweetener neohesperidin dihydrochalcone (NHDC) is a precursor for anthocyanins and
has been reported to have various bioactivities, including antioxidant and hepatitis inhibitory …

Neohesperidin dihydrochalcone ameliorates high-fat diet-induced glycolipid metabolism disorder in rats

Y Xiao, D Su, X Hu, G Yang, Y Shan - Journal of Agricultural and …, 2022 - ACS Publications
High-fat diet (HFD) is closely related to the formation of metabolic diseases. Studies have
confirmed that neohesperidin dihydrochalcone (NHDC) possesses the biological activity of …

Cyanidin-3-O-β-glucoside inhibits iNOS and COX-2 expression by inducing liver X receptor alpha activation in THP-1 macrophages

Q Wang, M Xia, C Liu, H Guo, Q Ye, Y Hu, Y Zhang… - Life sciences, 2008 - Elsevier
Anthocyanins belong to a large and widespread group of water-soluble phytochemicals and
exhibit potent antioxidative and anti-inflammatory properties; however, the molecular …

[HTML][HTML] Neohesperidin dihydrochalcone and neohesperidin dihydrochalcone-O-glycoside attenuate subcutaneous fat and lipid accumulation by regulating PI3K/AKT …

M Kwon, Y Kim, J Lee, JA Manthey, Y Kim, Y Kim - Nutrients, 2022 - mdpi.com
Neohesperidin dihydrochalcone (NHDC), a semi-natural compound from bitter orange, is an
intense sweetener. The anti-obesity effects of NHDC and its glycosidic compound, NHDC-O …

Cerasus humilis Cherry Polyphenol Reduces High-Fat Diet-Induced Obesity in C57BL/6 Mice by Mitigating Fat Deposition, Inflammation, and Oxidation

S Liu, X Chang, J Yu, W Xu - Journal of agricultural and food …, 2020 - ACS Publications
This study aimed to determine the anti-obesity effects and mechanisms of Cerasus humilis
polyphenol (CHP) in C57BL/6 obese mice and 3T3-L1 cells. High-performance liquid …

α-Monoglucosyl hesperidin but not hesperidin induces brown-like adipocyte formation and suppresses white adipose tissue accumulation in mice

S Nishikawa, T Hyodo, T Nagao… - Journal of agricultural …, 2019 - ACS Publications
Hesperidin (HES) is a flavanone glycoside found in citrus peel that contributes to its bitter
taste. It has low water solubility and poor oral bioavailability. To improve its solubility and …

Anti-obese effects and signaling mechanisms of Chaenomeles sinensis extracts in 3T3-L1 preadipocytes and obese mice fed a high-fat diet

DH Kim, B Kwon, SJ Kim, HJ Kim, SI Jeong… - Herbal Formula …, 2017 - koreascience.kr
Obesity is one of the most serious health problem because it induced numerous metabolic
syndrome and increases the incidence of various disease, including diabetes, hypertension …

Neohesperidin Dihydrochalcone Improves Hyperglycemia and Insulin Resistance in Diabetic Zebrafish

F Tao, P Wang, Z Dai, C Zhang, D Li… - ACS Food Science & …, 2023 - ACS Publications
Neohesperidin dihydrochalcone (NHDC), a bicyclic flavonoid compound, has many
important physiological functions. However, the underlying hypoglycemic mechanism of …

GC‐(4→8)‐GCG, A Proanthocyanidin Dimer from Camellia ptilophylla, Modulates Obesity and Adipose Tissue Inflammation in High‐Fat Diet Induced Obese Mice

J Peng, Y Jia, T Hu, J Du, Y Wang… - Molecular nutrition & …, 2019 - Wiley Online Library
Scope Excessive fat accumulation in adipose tissue leads to obesity and related chronic
inflammation. This study aims to examine the effects of gallocatechin‐(4→ 8)‐gallocatechin …

Glucosyl hesperidin has an anti-diabetic effect in high-fat diet-induced obese mice

H Yoshida, R Tsuhako, C Sugita… - Biological and …, 2021 - jstage.jst.go.jp
Glucosyl hesperidin (GH) is a water-soluble derivative of hesperidin, a citrus flavonoid. GH
has various pharmacological effects, such as hypolipidemic and hypouricemic effects, and …