[HTML][HTML] Antibody drug conjugate: the “biological missile” for targeted cancer therapy
Z Fu, S Li, S Han, C Shi, Y Zhang - Signal transduction and targeted …, 2022 - nature.com
Antibody–drug conjugate (ADC) is typically composed of a monoclonal antibody (mAbs)
covalently attached to a cytotoxic drug via a chemical linker. It combines both the …
covalently attached to a cytotoxic drug via a chemical linker. It combines both the …
Unlocking the potential of antibody–drug conjugates for cancer therapy
Nine different antibody–drug conjugates (ADCs) are currently approved as cancer
treatments, with dozens more in preclinical and clinical development. The primary goal of …
treatments, with dozens more in preclinical and clinical development. The primary goal of …
[HTML][HTML] Antibody-drug conjugates: the paradigm shifts in the targeted cancer therapy
Cancer is one of the deadliest diseases, causing million of deaths each year globally.
Conventional anti-cancer therapies are non-targeted and have systemic toxicities limiting …
Conventional anti-cancer therapies are non-targeted and have systemic toxicities limiting …
[HTML][HTML] Potential of antibody–drug conjugates (ADCs) for cancer therapy
The primary purpose of ADCs is to increase the efficacy of anticancer medications by
minimizing systemic drug distribution and targeting specific cells. Antibody conjugates …
minimizing systemic drug distribution and targeting specific cells. Antibody conjugates …
[HTML][HTML] A comprehensive review of key factors affecting the efficacy of antibody drug conjugate
A Samantasinghar, NP Sunildutt, F Ahmed… - Biomedicine & …, 2023 - Elsevier
Abstract Antibody Drug Conjugate (ADC) is an emerging technology to overcome the
limitations of chemotherapy by selectively targeting the cancer cells. ADC binds with an …
limitations of chemotherapy by selectively targeting the cancer cells. ADC binds with an …
Antibody‐drug conjugates: Promising and efficient tools for targeted cancer therapy
H Nasiri, Z Valedkarimi… - Journal of cellular …, 2018 - Wiley Online Library
Over the recent decades, the use of antibody–drug conjugates (ADCs) has led to a
paradigm shift in cancer chemotherapy. Antibody–based treatment of various human tumors …
paradigm shift in cancer chemotherapy. Antibody–based treatment of various human tumors …
[HTML][HTML] Antibody–drug conjugates—a tutorial review
Antibody–drug conjugates (ADCs) are a family of targeted therapeutic agents for the
treatment of cancer. ADC development is a rapidly expanding field of research, with over 80 …
treatment of cancer. ADC development is a rapidly expanding field of research, with over 80 …
Antibody–drug conjugates for cancer
CH Chau, PS Steeg, WD Figg - The Lancet, 2019 - thelancet.com
Antibody–drug conjugates (ADCs) are immunoconjugates comprised of a monoclonal
antibody tethered to a cytotoxic drug (known as the payload) via a chemical linker. The ADC …
antibody tethered to a cytotoxic drug (known as the payload) via a chemical linker. The ADC …
[HTML][HTML] Antibody–drug conjugates for cancer therapy
Antibody–drug conjugates (ADCs) are novel drugs that exploit the specificity of a
monoclonal antibody (mAb) to reach target antigens expressed on cancer cells for the …
monoclonal antibody (mAb) to reach target antigens expressed on cancer cells for the …
Antibody–drug conjugates come of age in oncology
C Dumontet, JM Reichert, PD Senter… - Nature Reviews Drug …, 2023 - nature.com
Antibody–drug conjugates (ADCs) combine the specificity of monoclonal antibodies with the
potency of highly cytotoxic agents, potentially reducing the severity of side effects by …
potency of highly cytotoxic agents, potentially reducing the severity of side effects by …