[HTML][HTML] Antibody drug conjugate: the “biological missile” for targeted cancer therapy

Z Fu, S Li, S Han, C Shi, Y Zhang - Signal transduction and targeted …, 2022 - nature.com
Antibody–drug conjugate (ADC) is typically composed of a monoclonal antibody (mAbs)
covalently attached to a cytotoxic drug via a chemical linker. It combines both the …

Unlocking the potential of antibody–drug conjugates for cancer therapy

JZ Drago, S Modi, S Chandarlapaty - Nature Reviews Clinical …, 2021 - nature.com
Nine different antibody–drug conjugates (ADCs) are currently approved as cancer
treatments, with dozens more in preclinical and clinical development. The primary goal of …

[HTML][HTML] Antibody-drug conjugates: the paradigm shifts in the targeted cancer therapy

D Aggarwal, J Yang, MA Salam, S Sengupta… - Frontiers in …, 2023 - frontiersin.org
Cancer is one of the deadliest diseases, causing million of deaths each year globally.
Conventional anti-cancer therapies are non-targeted and have systemic toxicities limiting …

[HTML][HTML] Potential of antibody–drug conjugates (ADCs) for cancer therapy

HE Marei, C Cenciarelli, A Hasan - Cancer Cell International, 2022 - Springer
The primary purpose of ADCs is to increase the efficacy of anticancer medications by
minimizing systemic drug distribution and targeting specific cells. Antibody conjugates …

[HTML][HTML] A comprehensive review of key factors affecting the efficacy of antibody drug conjugate

A Samantasinghar, NP Sunildutt, F Ahmed… - Biomedicine & …, 2023 - Elsevier
Abstract Antibody Drug Conjugate (ADC) is an emerging technology to overcome the
limitations of chemotherapy by selectively targeting the cancer cells. ADC binds with an …

Antibody‐drug conjugates: Promising and efficient tools for targeted cancer therapy

H Nasiri, Z Valedkarimi… - Journal of cellular …, 2018 - Wiley Online Library
Over the recent decades, the use of antibody–drug conjugates (ADCs) has led to a
paradigm shift in cancer chemotherapy. Antibody–based treatment of various human tumors …

[HTML][HTML] Antibody–drug conjugates—a tutorial review

S Baah, M Laws, KM Rahman - Molecules, 2021 - mdpi.com
Antibody–drug conjugates (ADCs) are a family of targeted therapeutic agents for the
treatment of cancer. ADC development is a rapidly expanding field of research, with over 80 …

Antibody–drug conjugates for cancer

CH Chau, PS Steeg, WD Figg - The Lancet, 2019 - thelancet.com
Antibody–drug conjugates (ADCs) are immunoconjugates comprised of a monoclonal
antibody tethered to a cytotoxic drug (known as the payload) via a chemical linker. The ADC …

[HTML][HTML] Antibody–drug conjugates for cancer therapy

U Hafeez, S Parakh, HK Gan, AM Scott - Molecules, 2020 - mdpi.com
Antibody–drug conjugates (ADCs) are novel drugs that exploit the specificity of a
monoclonal antibody (mAb) to reach target antigens expressed on cancer cells for the …

Antibody–drug conjugates come of age in oncology

C Dumontet, JM Reichert, PD Senter… - Nature Reviews Drug …, 2023 - nature.com
Antibody–drug conjugates (ADCs) combine the specificity of monoclonal antibodies with the
potency of highly cytotoxic agents, potentially reducing the severity of side effects by …