Imipramine is a tricyclic antidepressant that has been approved for treating depression and
anxiety in patients and animals and that has relatively mild side effects. However, the …

Hepatic steatosis is known to precede a continuum of events that lead to hepatic metabolic
dysfunction, inflammation and carcinogenesis. Recently, studies have linked xenobiotic …

BACKGROUND/AIMS: Obesity is a risk factor for glucose intolerance, steatosis, and
oxidative stress, characteristics of nonalcoholic fatty liver disease. Bromocriptine may have …

Simple Summary Mirtazapine, a tetracyclic antidepressant, acts through noradrenergic and
specific serotonergic systems. Consequently, it was recently applied in major depressive …

Aim The valuable effects of metformin (MET) and morin (MOR) in the improvement of NAFLD
have been proposed, nevertheless, their combination impacts were not investigated so far …

Abstract Background Leucine stimulates Sirt1 and AMPK signaling in vitro and in vivo. Since
metformin converges on the same pathway, we have tested the ability of leucine to amplify …

Previously we reported that a high fat, high sugar (HFHS) diet induced adiposity,
hyperinsulinaemia, hyperleptinaemia, hypertriglyceridaemia and increased liver mass in …

Fat-induced hepatic insulin resistance (FIHIR) in obesity induced by high-fat diet leads to
ectopic lipid accumulation and may contribute to the pathogenesis of type 2 diabetes. We …

Risperidone, a second-generation antipsychotic drug used for schizophrenia treatment with
less-severe side effects, has recently been applied in major depressive disorder treatment …

Obesity is associated with an increased risk for the development of type 2 diabetes and
vascular complications. Advanced glycation end products are increased in adipose tissue …