We previously found that thiamine mitigates metabolic disorders in spontaneously
hypertensive rats, harboring defects in glucose and fatty acid metabolism. Mutation of …

Trimethylamine N-oxide (TMAO) is an oxidation product of trimethylamine (TMA) and is
present in many aquatic foods. Here, we investigated the effects of TMAO on glucose …

Western diets contribute to metabolic diseases. However, the effects of various diets and
epigenetic mechanisms are mostly unknown. Here, six week-old C57BL/6J male and female …

Aims The therapeutic properties of anti-hypertensive medications that extend beyond blood
pressure lowering have started to become important clinical targets in recent years. This …

Obesity is a large and growing global health problem with few effective therapies. The
present study investigated metabolic and physiological benefits of nicotinamide N …

Mineralocorticoid receptor (MR) activation plays an important role in hepatic insulin
resistance. However, the precise mechanisms by which MR activation promotes hepatic …

BACKGROUND & AIMS: Despite major public health concern, therapy for non-alcoholic fatty
liver, the liver manifestation of the metabolic syndrome often associated with insulin …

Rats neonatally treated with monosodium L‐glutamate (MSG) are deeply dysfunctional in
adulthood. We explored the effect of an oral low dose of metformin treatment in male MSG …

Aims Potential anti-obesity effects of quinizarin, a plant anthraquinone, were investigated
using 3 T3-L1 preadipocyte cells and high-fat diet (HD)-induced obese mice. Main method …

Therapeutic potential of metformin in obese/diabetic patients has been associated to its
ability to combat insulin resistance. However, it remains largely unknown the signaling …