Pancreatic adenocarcinoma: Molecular drivers and the role of targeted therapy

B Al-Share, N Hammad, M Diab - Cancer and Metastasis Reviews, 2021 - Springer
Prognosis from pancreatic ductal adenocarcinoma (PDAC) continues to be poor despite the
many efforts channeled to improve its management. Although the mainstay treatment is still …

Pancreatic cancer: new approaches to drug therapy

VJ Picozzi - International Journal of Surgery, 2024 - journals.lww.com
Outcomes in pancreatic ductal adenocarcinoma (PDAC) remain poor due to a variety of
biological, clinical, and societal factors. However, in recent years, PDAC has seen 1) …

Pancreatic ductal adenocarcinoma: State-of-the-art 2017 and new therapeutic strategies

M Chiaravalli, M Reni, EM O'Reilly - Cancer treatment reviews, 2017 - Elsevier
Pancreatic ductal adenocarcinoma (PDAC) is a fatal malignancy with an overall 5-year
survival of 8% for all stages combined. The majority of patients present with stage IV disease …

[HTML][HTML] Molecular Classification and Pathogenesis of Pancreatic Adenocarcinoma and Targeted Therapies: A Review

SM Ruff, TM Pawlik - Frontiers in Bioscience-Landmark, 2024 - imrpress.com
Pancreatic adenocarcinoma (PDAC) is disease with a 5-year survival of only 12%. Many
patients with PDAC present with late-stage disease and even early-stage disease can often …

Pancreatic cancer: progress in systemic therapy

L Perkhofer, TJ Ettrich, T Seufferlein - Gastrointestinal Tumors, 2015 - karger.com
Background: Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer-
related deaths in the Western world. Due to lack of specific symptoms and no accessible …

New therapeutic targets in pancreatic cancer

E Lai, M Puzzoni, P Ziranu, A Pretta, V Impera… - Cancer treatment …, 2019 - Elsevier
Pancreatic ductal adenocarcinoma (PDAC) is associated with poor survival. Of all newly
diagnosed patients, only about 20% can benefit from a potentially curative surgical …

Pharmacotherapeutic options for pancreatic ductal adenocarcinoma

M Sardar, A Recio-Boiles, K Mody… - Expert Opinion on …, 2022 - Taylor & Francis
Introduction Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy projected to
be the 2nd leading cause of cancer related death in the USA by 2030. This manuscript …

[HTML][HTML] Perspectives in the treatment of pancreatic adenocarcinoma

A Cid-Arregui, V Juarez - World journal of gastroenterology: WJG, 2015 - ncbi.nlm.nih.gov
Pancreatic ductal adenocarcinoma (PDAC) is an incurable lethal disease whose incidence
rate is growing. There is no effective screening for detection of early stage tumors and, in …

Pancreatic cancer: pathogenesis, screening, diagnosis, and treatment

LD Wood, MI Canto, EM Jaffee, DM Simeone - Gastroenterology, 2022 - Elsevier
Pancreatic ductal adenocarcinoma (PDAC) is a clinically challenging cancer, due to both its
late stage at diagnosis and its resistance to chemotherapy. However, recent advances in our …

Pancreatic ductal adenocarcinoma: Emerging therapeutic strategies

DC Osei-Bordom, N Serifis, ZJ Brown, DB Hewitt… - Surgical Oncology, 2022 - Elsevier
The seventh leading cause of cancer-related death globally, pancreatic ductal
adenocarcinoma (PDAC) involves the exocrine pancreas and constitutes greater than 90 …