Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous
system that is believed to have an autoimmune etiology. As MS is the most common …

The role of CD8+ T cells in multiple sclerosis (MS) and its animal models has been
enigmatic. Most studies of MS have focused on the role of CD4+ Th1 T cells and many …

Multiple sclerosis (MS) is a common neurological disorder of putative autoimmune origin.
Clinical studies delineate abnormal expression of specific cytokines over the course of …

Multiple sclerosis (MS), a neuroinflammatory disease that affects millions worldwide, is
widely thought to be autoimmune in etiology. Historically, research into MS pathogenesis …

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system
(CNS). Significant progress has been made in our understanding of the etiology of MS. MS …

Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS)
characterized by multi-focal demyelination, axonal loss, and immune cell infiltration …

Multiple sclerosis (MS) is a multifocal demyelinating disease of the central nervous system
pathologically characterized by lesions of infiltrating macrophages and T cells. Multiple lines …

Multiple sclerosis (MS) is a complex disease of the central nervous system (CNS), which is
believed to be immune-mediated. While CD4+ T cells have been the main suspects for …

T lymphocytes play a central role in the pathogenesis of multiple sclerosis (MS)(Zhang et al.,
1992). Both CD4+ and CD8+ T cells have been demonstrated in MS lesions, with CD4+ T …

Autoreactive CD4+ T cells, which target antigens in central nervous system (CNS) myelin,
are widely believed to play a critical role in the pathogenesis of multiple sclerosis (MS) in …