The role of DNA methylation in gene regulation

PA Bommarito, RC Fry - Toxicoepigenetics, 2019 - Elsevier
DNA methylation is often thought to have a repressive effect on gene expression. However,
… It further focuses on the mechanisms by which DNA methylation can repress or activate gene

Evidence that direct inhibition of transcription factor binding is the prevailing mode of gene and repeat repression by DNA methylation

S Kaluscha, S Domcke, C Wirbelauer, MB Stadler… - Nature …, 2022 - nature.com
repression through DNA methylation of CpG-rich regulatory regions that drive genes and …
genome-wide DNA methylation evolved as an efficient means to repress repetitive elements …

Sensitivity of transcription factors to DNA methylation

É Héberlé, AF Bardet - Essays in biochemistry, 2019 - portlandpress.com
… acts to repress transcription and has a wide variety of geneticDNA methylation in cancer,
the role of DNA methylation in the … Although DNA methylation has long been thought to repress

The diverse roles of DNA methylation in mammalian development and disease

MVC Greenberg, D Bourc'his - Nature reviews Molecular cell biology, 2019 - nature.com
… re-establishment of DNA methylation in embryonic, germline … into DNA methylation gained
from studying genetic diseases. … imprinting, DNA methylation has a major role in repressing

TET repression and increased DNMT activity synergistically induce aberrant DNA methylation

H Takeshima, T Niwa, S Yamashita… - The Journal of …, 2020 - Am Soc Clin Investig
genes are repressed by exposure to chronic inflammation. To explore the mechanisms of
methylation … changes of DNA methylation writer (Dnmt) and eraser (Tet) genes in mouse gland–…

Chromatin dysregulation and DNA methylation at transcription start sites associated with transcriptional repression in cancers

M Ando, Y Saito, G Xu, NQ Bui… - Nature …, 2019 - nature.com
… have higher levels of gene promoter methylation compared with HPV-… of transcriptional
repression from DNA methylation at … transcriptional repression associated with broad repressive

The complex interplay between DNA methylation and miRNAs in gene expression regulation

A Fuso, T Raia, M Orticello, M Lucarelli - Biochimie, 2020 - Elsevier
repress mRNA expression by binding to target messenger; DNA methylation of miRNAs
genes can suppress miRNAs production but, in turn, miRNAs can repress DNMTs causing …

DNA methylation-free Arabidopsis reveals crucial roles of DNA methylation in regulating gene expression and development

L He, H Huang, M Bradai, C Zhao, Y You, J Ma… - Nature …, 2022 - nature.com
… that DNA methylation has a strong dose-dependent effect on gene expression and repression
of … Thus, our results confirm the accepted repressive effect of DNA methylation on gene

DNA methylation and regulation of gene expression: Guardian of our health

GA Dhar, S Saha, P Mitra, R Nag Chaudhuri - The Nucleus, 2021 - Springer
DNA methylation in a locus, it can serve as a repressiveDNA methylation levels in a locus
regulates gene expression intricately. Generally, DNA methylation is known to be a repressive

Enhancer DNA methylation: implications for gene regulation

A Angeloni, O Bogdanovic - Essays in biochemistry, 2019 - portlandpress.com
… This usually acts to repress transcription and has a wide variety of genetic uses. This issue
explores DNA methylation in cancer, the role of DNA methylation in the oocyte and provides …