Complexity of TNF-α signaling in heart disease
F Rolski, P Błyszczuk - Journal of clinical medicine, 2020 - mdpi.com
… -TNF-α treatment in patients with and without heart disease and describes the involvement
of TNF-α signaling in a number of animal models of cardiovascular diseases. We specifically …
of TNF-α signaling in a number of animal models of cardiovascular diseases. We specifically …
Inflammation and resolution signaling in cardiac repair and heart failure
… Unresolved inflammation is a key mediator of advanced heart failure. Especially, damage, …
diseases, particularly in cardiac pathology. After a significant cardiac injury like a heart attack, …
diseases, particularly in cardiac pathology. After a significant cardiac injury like a heart attack, …
Inflammatory cytokines and chemokines as therapeutic targets in heart failure
A Hanna, NG Frangogiannis - Cardiovascular Drugs and Therapy, 2020 - Springer
… Experimental evidence demonstrating involvement of IL-6 signaling in the pathogenesis
of heart failure suggests that treatment with tocilizumab may also be effective in …
of heart failure suggests that treatment with tocilizumab may also be effective in …
The role of signaling pathways of inflammation and oxidative stress in development of senescence and aging phenotypes in cardiovascular disease
J Papaconstantinou - Cells, 2019 - mdpi.com
… tumor necrosis factor α and bacterial lipopolysaccharide (TNFα, LPS) and mitochondrial ETC
dysfunction (ROS signals) … of senescence, aging and diseases of oxidative stress including …
dysfunction (ROS signals) … of senescence, aging and diseases of oxidative stress including …
NFkappaB is a key player in the crosstalk between inflammation and cardiovascular diseases
A Fiordelisi, G Iaccarino, C Morisco, E Coscioni… - International journal of …, 2019 - mdpi.com
… In this review, we deal with the recent findings of the role of inflammation in cardiac diseases…
increased GPCRs downstream signaling (enhanced cAMP and reduced TNF-α production) […
increased GPCRs downstream signaling (enhanced cAMP and reduced TNF-α production) […
Flavonoids as natural anti-inflammatory agents targeting nuclear factor-kappa B (NFκB) signaling in cardiovascular diseases: a mini review
… (CVDs) such as angina, hypertension, myocardial ischemia, and heart failure are the leading
causes of morbidity and mortality worldwide. One of the major transcription factors widely …
causes of morbidity and mortality worldwide. One of the major transcription factors widely …
The role of tumor necrosis factor alpha (TNF-α) in autoimmune disease and current TNF-α inhibitors in therapeutics
D Jang, AH Lee, HY Shin, HR Song, JH Park… - International journal of …, 2021 - mdpi.com
… The impact of TNF-α signaling on each type of autoimmune disease will be introduced in
this … The worsening of heart failure and increased risk of developing tuberculosis as well as …
this … The worsening of heart failure and increased risk of developing tuberculosis as well as …
Stem Cell‐Derived Exosomes Prevent Aging‐Induced Cardiac Dysfunction through a Novel Exosome/lncRNA MALAT1/NF‐κB/TNF‐α Signaling Pathway
B Zhu, L Zhang, C Liang, B Liu, X Pan… - Oxidative medicine …, 2019 - Wiley Online Library
… However, the signaling pathway connecting oxidative stress, inflammation, and aging … to
alleviate aging-associated cardiovascular disease [4, 7]. Tumor necrosis factor-α (TNF-α), one of …
alleviate aging-associated cardiovascular disease [4, 7]. Tumor necrosis factor-α (TNF-α), one of …
Angiogenic endothelial cell signaling in cardiac hypertrophy and heart failure
R Gogiraju, ML Bochenek, K Schäfer - Frontiers in cardiovascular …, 2019 - frontiersin.org
… the disease. In this review article, we will explore possible causes underlying defects in
angiogenic signaling in the hypertrophied heart resulting in a mismatch between cardiac oxygen …
angiogenic signaling in the hypertrophied heart resulting in a mismatch between cardiac oxygen …
Inflammatory cytokines in the pathogenesis of cardiovascular disease and cancer
…, ML Hakim, MS Ahammed, A Kabir… - SAGE open …, 2020 - journals.sagepub.com
… coronary artery disease, myocardial infarction, heart failure and other adverse cardiac events.
… the activation of PI3K/Akt and MAPK signaling. Moreover, the expression of circulating …
… the activation of PI3K/Akt and MAPK signaling. Moreover, the expression of circulating …
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