Biological signatures of Alzheimer's disease

P Sharma, A Sharma, F Fayaz… - Current Topics in …, 2020 - ingentaconnect.com
… If the current trend continues, the cases of Alzheimer's disease will increase four times in the
… distribution of the pathological changes in the neocortex in alzheimer disease. Proc. Natl. …

[HTML][HTML] Using path signatures to predict a diagnosis of Alzheimer's disease

…, Alzheimer's Disease Neuroimaging Initiative - PloS one, 2019 - journals.plos.org
… , the phase of MCI ends with a marked decline in cognitive function as the disease pathology
… Is the Subject Area "Alzheimer's disease diagnosis and management" applicable to this …

[HTML][HTML] Biomarker-based signature of Alzheimer's disease in pre-MCI individuals

E Chipi, N Salvadori, L Farotti, L Parnetti - Brain Sciences, 2019 - mdpi.com
… Structural abnormalities in these regions represent a marker of AD pathology, so-called “AD-signature
[134,135]. The regions have been previously described as the Default Mode …

Proteomic signatures of brain regions affected by tau pathology in early and late stages of Alzheimer's disease

CF Mendonça, M Kuras, FCS Nogueira, I Plá… - … of disease, 2019 - Elsevier
… tau pathology at different stages of AD. Although we identified commonly regulated proteins
and pathways during disease … In addition, a distinct proteomic signature was found between …

Molecular signatures underlying neurofibrillary tangle susceptibility in Alzheimer's disease

M Otero-Garcia, SU Mahajani, D Wakhloo, W Tang… - Neuron, 2022 - cell.com
… decline in Alzheimer’s disease (AD). However, the molecular signatures that distinguish …
identified both shared and cell-type-specific signatures. NFT-bearing neurons shared a marked …

[HTML][HTML] Retinal pathological features and proteome signatures of Alzheimer's disease

Y Koronyo, A Rentsendorj, N Mirzaei, GC Regis… - Acta …, 2023 - Springer
disease progression in the brain remain largely unknown. To better understand the pathological
… , and atrophy correlated with severity of brain Aβ pathology, tauopathy, and atrophy, and …

[HTML][HTML] Comparing cortical signatures of atrophy between late-onset and autosomal dominant Alzheimer disease

A Dincer, BA Gordon, A Hari-Raj, SJ Keefe, S Flores… - NeuroImage: Clinical, 2020 - Elsevier
… a signature of cortical regions of interest preferentially affected by Alzheimer disease (AD)
pathology … Since late-onset Alzheimer disease (LOAD) participants tend to have age-related …

Brain metabolic signatures across the Alzheimer's disease spectrum

A Sala, C Caprioglio, R Santangelo, EG Vanoli… - European journal of …, 2020 - Springer
… We identified hypometabolism signatures for each clinical atypical variant within the AD …
paradigm of neurodegenerative disease, positing that the pathology associated with these …

A machine learning approach to identify a circulating MicroRNA signature for Alzheimer disease

X Zhao, J Kang, V Svetnik, D Warden… - The journal of …, 2020 - academic.oup.com
Alzheimer disease (AD) diagnosis. Our results indicate that the serum microRNA signature
Alzheimer disease (AD) 6 is the most common form of dementia with increasing prevalence …

A brain proteomic signature of incipient Alzheimer's disease in young APOE ε4 carriers identifies novel drug targets

JA Roberts, VR Varma, Y An, S Varma, J Candia… - Science …, 2021 - science.org
signature. In steps 3 and 4, we tested associations between the incipient AD proteomic
signature and both AD pathologypathology. In step 6b, we validated the incipient AD proteomic …