… Here we give an introduction and overview to the link between tumorigenesis and stromal
… for this altered stromal collagen remodeling, the cancer associated fibroblasts (CAFs), and …

… stromal response, cancer-associated fibroblasts (CAFs) are of particular interest. CAFs are
highly differentiated and activated fibroblasts … In the healthy colon tissue, resting fibroblasts …

… The stroma consists of many different cell types, but, in this review, we will focus on … are the
main producers of ECM components and ECM-remodeling enzymes that contribute to stromal …

… Cancer-associated fibroblasts, the major stromal cells of most solid cancers such as breast
and pancreatic cancers, … of ECM remodeling and in stroma cell (BMDCs, endothelial cells and …

… into tumor tissues through stromal-derived factor-1 (SDF-1) to promote angiogenesis (47).
CAFs degrade the extracellular stroma by releasing some matrix remodeling … of tumor cells. By …

… The leading cell in this motile cohort is usually a fibroblast that, unlike the follower tumor
cells, employs Rho-ROCK signaling and protease-mediated stromal remodeling to effectively …

… into cancer-associated fibroblasts (CAFs). These cells modulate cancer metastasis through
synthesis and remodelling of … of stromal fibroblasts initially originate from local fibroblasts that …

… stromal cells, cancer associated fibroblasts (CAFs), and the ECM they produce, to highlight
the role of CAFs in tumorigenesis accounting for the Cancer … substantial stromal remodeling (…

… Cancer-associated fibroblasts (CAFs) are abundant and extremely influential in this process
… within the evolving tumour stroma, ranging from quiescent fibroblasts to highly proliferative …

… most solid tumors is dependent upon remodeling ‘stroma’, composed of cancer-associated …
identifying the stroma-dependent mechanisms that regulate cancer-associated inflammation …