Erlotinib versus etoposide/cisplatin with radiation therapy in unresectable stage III epidermal growth factor receptor mutation-positive non-small cell lung cancer: a …

L Xing, G Wu, L Wang, J Li, J Wang, Z Yuan… - International Journal of …, 2021 - Elsevier
study aimed to compare erlotinib (E) and etoposide/cisplatin (EP) with concurrent radiation
therapy (RT) for patients with stage IIIA/B unresectable advanced non-small cell lung cancer

Enhancing anti-cancer activity of erlotinib by antibody conjugated nanofibrin-in vitro studies on lung adenocarcinoma cell lines

SW Vedakumari, R Senthil, S Sekar, CS Babu… - Materials Chemistry and …, 2019 - Elsevier
… is quite challenging in treating most types of cancer. Herein, we report the synthesis of
antibody linked fibrin nanoparticles for the treatment of non-small cell lung cancer (NSCLC). Wet …

Designed DNA nanostructure grafted with erlotinib for non-small-cell lung cancer therapy

Y Wang, J Cheng, D Zhao, Y Liu, T Luo, YF Zhong… - Nanoscale, 2020 - pubs.rsc.org
… tissues were further analyzed by the histological studies and immunohistochemical assay. …
tumor cells for the 6 × 6 × 64 nt-Er treated group. TUNEL staining verified more apoptotic cells

Population pharmacokinetics of Erlotinib in patients with non–small cell Lung Cancer: its application for individualized dosing regimens in older patients

E Cardoso, M Guidi, N Khoudour… - Clinical …, 2020 - Elsevier
… By using a population PK approach, the aims of the present study were to describe the PK
profile of erlotinib in adult patients with NSCLC from a real-world setting, to identify factors …

[HTML][HTML] KCa channel blockers increase effectiveness of the EGF receptor TK inhibitor erlotinib in non-small cell lung cancer cells (A549)

F Glaser, P Hundehege, E Bulk, LM Todesca… - Scientific Reports, 2021 - nature.com
… In the present study we followed up on K Ca 3.1 channels … in erlotinib-ressitance of NSCLC
cells using the A549-3R cellcells, we generated partially erlotinib-resistant A549-3R cells

[HTML][HTML] Phase II Trial of Cabozantinib Plus Erlotinib in Patients With Advanced Epidermal Growth Factor Receptor (EGFR)-Mutant Non-small Cell Lung Cancer With …

KL Reckamp, PH Frankel, N Ruel, PC Mack… - Frontiers in …, 2019 - frontiersin.org
… If 1 or more patients had an objective response, the study was to continue enrollment to the
… This study also obtained a tumor growth estimate for patient's disease on the last erlotinib-…

[HTML][HTML] Transformation to small cell lung cancer and activation of KRAS during long‑term erlotinib maintenance in a patient with non‑small cell lung cancer: A case …

Y Gu, X Zhu, B Cao, X Wu, X Tong… - Oncology …, 2019 - spandidos-publications.com
… In conclusion, the present study reports a complex and diversified tumor evolution under
erlotinib treatment, by phenotypic transformation from ADC to SCLC with the acquisition of a …

A randomized Phase 2 study to compare erlotinib with or without bevacizumab in previously untreated patients with advanced non–small cell lung cancer with EGFR …

Y Lee, HR Kim, MH Hong, KH Lee, KU Park, GK Lee… - Cancer, 2023 - Wiley Online Library
… , 12-15 whereas other studies failed to demonstrate any PFS benefit. Thus, this study aimed
to … , bevacizumab, with the EGFR-TKI, erlotinib, in improving clinical outcomes in previously …

LHX6 Affects Erlotinib Resistance and Migration of EGFR-Mutant Non-Small-Cell Lung Cancer HCC827 Cells Through Suppressing Wnt/β-Catenin Signaling

Q Wang, J Liao, Z He, Y Su, D Lin, L Xu… - OncoTargets and …, 2020 - Taylor & Francis
… reported to contribute to erlotinib resistance in non-small-cell lung cancer (NSCLC) through
… -TKIs in erlotinib-resistant NSCLC HCC827 (HCC827/ER) cells remain unknown. This study

Erlotinib-valproic acid liquisolid formulation: evaluating oral bioavailability and cytotoxicity in erlotinib-resistant non-small cell lung cancer cells

K Patel, R Doddapaneni, M Patki, V Sekar, A Bagde… - AAPS …, 2019 - Springer
… in TKI-resistance lung cancer cells could reverse the resistant phenotype in tumor cells,
thereby … Research work was aimed to address the following key problems associated with …