GBP1 promotes erlotinib resistance via PGK1‑activated EMT signaling in non‑small cell lung cancer

L Cheng, L Gou, T Wei, J Zhang - … Journal of Oncology, 2020 - spandidos-publications.com
study, GBP1 was significantly upregulated in erlotinib‑resistant cells, compared with
erlotinib‑sensitive cells… GBP1 expression contributed to erlotinib resistance, while decreased …

[HTML][HTML] Tyrosine kinase inhibitors for the treatment of EGFR mutation-positive non–small-cell lung cancer: a clash of the generations

R Shah, JF Lester - Clinical lung cancer, 2020 - Elsevier
tumor cells that carry T790M) will be greater in afatinib-resistant tumor cells than in
erlotinib-resistant tumor cells… In the phase III EURTAC study, erlotinib conferred significant PFS …

Cost-effectiveness of afatinib, gefitinib, erlotinib and pemetrexed-based chemotherapy as first-line treatments for advanced non-small cell lung cancer in China

X Gu, Q Zhang, YB Chu, YY Zhao, YJ Zhang, D Kuo… - Lung Cancer, 2019 - Elsevier
erlotinib [13]. Currently, afatinib has been approved as a first-line treatment for patients with
advanced non-small cell lung cancer … The primary objective of this study is to compare the …

… quantitative detection of afatinib, erlotinib, gefitinib, icotinib, osimertinib and their metabolites in plasma samples of patients with non-small cell lung cancer using …

X Xiong, Y Zhang, Z Wang, C Zhou, P Yang, X Du… - Clinica Chimica …, 2022 - Elsevier
… In the present research, we proposed and validated a novel method for the simultaneous
analysis of five EGFR-… Informed consent was obtained from all individuals included in this study. …

[HTML][HTML] Safety and clinical activity of atezolizumab plus erlotinib in patients with non-small-cell lung cancer

CM Rudin, A Cervantes, A Dowlati, B Besse, B Ma… - ESMO open, 2023 - Elsevier
… In the phase I/II KEYNOTE-021 study that evaluated the feasibility of combining erlotinib
or gefitinib with pembrolizumab, pembrolizumab combined with gefitinib was found not to be …

Treatment of non-small cell lung cancer with EGFR-mutations

K Yoneda, N Imanishi, Y Ichiki, F Tanaka - Journal of UOEH, 2019 - jstage.jst.go.jp
Erlotinib is also a competitive inhibitor of TK, and gefitinib or … 2007): Randomized phase III
study of cisplatin plus irinotecan … -small-cell lung cancer: Four-Arm Cooperative Study in Japan…

Quantitative modeling of tumor dynamics and development of drug resistance in non‐small cell lung cancer patients treated with erlotinib

A Yin, GDM Veerman, JGC van Hasselt… - CPT …, 2024 - Wiley Online Library
… This study aims to characterize the tumor … -small cell lung cancer treated with erlotinib, and
investigate the relationship between baseline circulating tumor DNA (ctDNA) data and tumor

Development of a fluorinated analogue of erlotinib for PET imaging of EGFR mutation–positive NSCLC

O Shamni, H Grievink, B Itamar, E Mishani… - Molecular Imaging and …, 2019 - Springer
… [ 11 C]erlotinib identifies non-small cell lung carcinoma (NSCLC) tumors … studies, [ 11 C]erlotinib
was co-injected with erlotinib (6.7 mg/kg) [20], whereas in the present study, erlotinib

Erlotinib versus gemcitabine plus cisplatin as neoadjuvant treatment of stage IIIA-N2 EGFR-mutant non-small-cell lung cancer: final overall survival analysis of the …

WZ Zhong, HH Yan, KN Chen, C Chen… - Signal transduction and …, 2023 - nature.com
… The EMERGING-CTONG 1103 study is the first randomised … targeted therapy with erlotinib
compared with standard … study and found that the median OS of neoadjuvant erlotinib

Epiregulin confers EGFR-TKI resistance via EGFR/ErbB2 heterodimer in non-small cell lung cancer

S Ma, L Zhang, Y Ren, W Dai, T Chen, L Luo, J Zeng… - Oncogene, 2021 - nature.com
… Consistent with previous studies, our results showed that EGF … to gefitinib or erlotinib in
EGFR-mutant cells. The predictive … erlotinib therapy was enrolled for the analysis in this study. …