… epithelia that would support simultaneous secretion and absorption of the ASL. In addition,
we sought to determine whether the small airway epithelium also secretes bicarbonate …

… secretion in distal airways is critical for airway mucosal defense. HCO 3 − /H + transport across
the apical membrane of airway surface epithelial … 3 − transport in surface epithelial cells of …

… Airway epithelia control the pH of airway surface liquid (ASL), thereby optimizing respiratory
defences. Active H + and HCO 3 − secretion by airway epithelial cells produce an ASL that …

… current by approximately twofold in epithelial and nonepithelial cells. We … secretion across
airway surface epithelium during inflammation and enhances electrogenic Cl − secretion …

… The latter mainly involves CFTR, the apical chloride/bicarbonate exchanger pendrin and
paracellular transport. Proton (H + ) secretion into ASL is crucial to maintain its relative acidity …

… depends on a balanced secretion of chloride and bicarbonate and the absorption … bicarbonate
secretion causes a lowering of the ASL pH which is involved in the change of the epithelia …

… Bicarbonate is a key component of human bile and impaired biliary bicarbonate secretion
is … Ciliated and goblet epithelial cells in the airways maintain the airway surface liquid (ASL) …

… in epithelial and non-epithelial cells. We conclude that pendrin mediates most … secretion
across airway surface epithelium during inflammation and enhances electrogenic Cl- secretion …

… Duodenal, intestinal, and colonic HCO 3 − regulation is crucial for epithelial defense against
acid and for mucus secretion, as well as for pH regulation [125,126,127]. Several reports …

… In the colon, bestrophin-2 is enriched in the basolateral membrane of goblet cells that
secrete mucin molecules at the epithelial surface. Notably, bestrophin-2 is highly permeable to …