… been explored in targeted protein degradation to date. In … targeted protein degradation and
review the major classes of E3 ligases that may be exploited to expand the PROTAC toolbox. …

… for targeting proteins, thereby expanding the scope of TPD platforms to include secreted …
Professor Laura MK Dassama is a chemical and structural biologist who uses tools of chemistry …

… Targeted Protein Degradation (TPD) strategies have also been explored to target previously
undruggable proteins… of the proteins targeted by PROTACs and the biological effects of their …

… validation and chemical tools to accelerate efforts in protein degradation. We anticipate …
Both small-molecule approaches to subverting E3 ligases offer an opportunity to expand the …

… expanding the range of substrates. In this review, we first provide a simple introduction of
protein degradation … , will not only provide powerful tools for biomedical research, but hold great …

… of the target protein. The broad … that target oncoproteins with tissue, tumour and subcellular
selectivity. In this Review, we first discuss the molecular basis of targeted protein degradation…

Of late, targeted protein degradation (TPD) has surfaced as a novel and innovative chemical
tool and therapeutic modality. By co-opting protein degradation pathways, TPD facilitates …

… Targeted protein degraders are extremely useful as biological tools for discovery research.
They have also been developed as novel therapeutics with several targeted protein …

… To expand the reach of TPD to degrade other “hard to drug” … synthesis, and molecular
biology, tools now exist to identify ligands for almost any protein. This is underscored by the recent …

… to E3 ligases remains crucial for expanding the set of E3 … for targeted protein degradation
of a given target of interest and ultimately expand the applicability of this modality to any protein …