Pathological alteration and therapeutic implications of sepsis-induced immune cell apoptosis

C Cao, M Yu, Y Chai - Cell death & disease, 2019 - nature.com
… Thus manipulating apoptosis could be a new therapeutic approach in sepsis. Further,
exploring potential therapeutic targets related to apoptosis will be valuable in reversing …

Signaling pathways and intervention therapies in sepsis

Y Zhang, B Ning - Signal Transduction and Targeted Therapy, 2021 - nature.com
… In a tentative exploration of hospital-treated sepsis data obtained from high-income … via
suppressing myocardial and serum inflammatory cytokines, apoptosis, and pyroptosis. STING-…

The potential immunological mechanisms of sepsis

X Zhang, Y Zhang, S Yuan, J Zhang - Frontiers in Immunology, 2024 - frontiersin.org
… of sepsis. We also try to explore the future direction of sepsis diagnosis and therapy in …
Inhibition of lymphocyte apoptosis has been demonstrated to lower sepsis mortality (70). …

Therapeutic potential of extracellular vesicles for sepsis treatment

SM Kronstadt, AE Pottash, D Levy, S Wang… - … therapeutics, 2021 - Wiley Online Library
… , anti-apoptotic, and immunomodulatory effects in sepsis models. The dual nature of EVs
in … One such new direction has been the exploration of cell-based therapeutics. Cell …

The role and mechanism of pyroptosis and potential therapeutic targets in sepsis: a review

X Zheng, W Chen, F Gong, Y Chen, E Chen - Frontiers in immunology, 2021 - frontiersin.org
… from apoptosis. A growing number of studies have investigated pyroptosis and its relationship
with … targets of pyroptosis have been highlighted to explore their therapeutic effect and …

Therapeutic potential of annexins in sepsis and COVID-19

L Mui, CM Martin, BJ Tschirhart, Q Feng - Frontiers in Pharmacology, 2021 - frontiersin.org
… to apoptosis, are promising therapeutic agents to reduce the severity of inflammatory
processes in COVID-19. However, the exact mechanism of COVID-19 coagulopathy is not fully …

Ferroptosis in sepsis: the mechanism, the role and the therapeutic potential

L Xl, Z Gy, CN - Frontiers in Immunology, 2022 - frontiersin.org
… non-apoptotic cell … sepsis can be confirmed and whether the exploration of ferroptosis as
a direction of intervention can bring a breakthrough in the treatment and management of sepsis

Apoptotic cell therapy for cytokine storm associated with acute severe sepsis

N Karbian, A Abutbul, R El-Amore, R Eliaz… - Cell Death & …, 2020 - nature.com
Apoptotic cell administration markedly improved the cytokine … -induced sepsis can be
successfully modified by apoptotic … , we were interested in exploring some of the major metabolic …

New strategies for treatment of infectious sepsis

PA Ward, F Fattahi - Journal of leukocyte biology, 2019 - academic.oup.com
… , often, apoptosis, especially in the setting of infectious sepsis. … cause cell damage and
apoptosis and are very prothrombotic … in septic mice would be an obvious potential therapeutic

Long noncoding RNA: regulatory mechanisms and therapeutic potential in sepsis

W Wang, N Yang, R Wen, CF Liu… - Frontiers in cellular and …, 2021 - frontiersin.org
… to actively explore the pathogenesis of sepsis. Moreover, … involved in sepsis-induced AKI
through regulation of apoptosis, … expected to serve as biomarkers and new therapeutic targets. …