… used as oral anti-cancer drugs in combination with thymidine phosphorylase inhibitor in the
treatment of refractory colorectal cancer. [ Citation 26 ] Upon uptake into the cells TFT can be …

… Metabolic alterations that are critical for cancer cell growth and metastasis are one of the
key hallmarks of cancer. Here, we show that thymidine kinase 1 (TK1) is significantly …

… Using a large-scale transcriptomic database and survival correlation screening, we identify
thymidine kinase 1 (TK1) as a key driver. The progression of HCC is robustly mitigated by …

… TK2 is a nuclear gene encoding the mitochondrial matrix protein thymidine kinase 2 (TK2),
a critical enzyme in the mitochondrial nucleotide salvage pathway. Deficiency of TK2 activity …

… of thymidine kinases from the TK1 family. A, alignment overview of TK1 family members
including thymidine kinases … performed with three of the thymidine kinases. The G. intestinalis …

… In this study, we evaluated the potential of nucleoside analogs and thymidine kinase-based
suicide genes. Among tested thymidine kinase variants, the humanized SR39 (SR39h) …

… It was reported that thymidine kinase activity is higher in the tumour than in normal tissue
from the same patient 17 . Furthermore, several studies report that high expression of TK1 …

BrdU (bromodeoxyuridine) and EdU (ethynyldeoxyuridine) have been largely utilized as the
means of monitoring DNA replication and cellular division. Although BrdU induces gene …

… On the other hand, the poor cellular uptake of GCV into the tumor cells may be an important
reason for the limited efficacy of HSV-TK/GCV gene therapy. In vitro, Rubsam et al. found …

… We here discuss cellular uptake and intracellular … in vitro thymidine kinase-mediated
phosphorylation of the anti-HIV agent zidovudine has been found to be blocked by thymidine [68]. …