… using herpes simplex virus thymidine kinase (HsvTK) and the mutagenic nucleoside analog
6-(β-d-2… We found that over-expression of NupC and NupG (nucleoside uptake-related inner …

… used as oral anti-cancer drugs in combination with thymidine phosphorylase inhibitor in the
treatment of refractory colorectal cancer. [ Citation 26 ] Upon uptake into the cells TFT can be …

… protein thymidine kinase 2 (TK2), a critical enzyme in the mitochondrial nucleotide salvage
… , indicating that despite nucleoside transport across the BBB, uptake efficiency is lower for …

… Figure 1Nucleotide metabolism in G. intestinalis. The parasite lacks many pathways in
nucleotide metabolism including ribonucleotide reductase (RNR) and thymidylate synthase (TS), …

… IN-8 prevented the uptake of all nucleosides tested, … uptake of both rU and dC with similar
potency (33 and 31 nM, respectively), further suggesting that the compound inhibits nucleoside …

… was strongly reduced in the presence of several nucleosides… AZT uptake was exhibited in
the presence of other nucleosides… the presence of several nucleosides, such as thymidine, 2′-…

… that measured the intracellular nucleotide concentrations of … monophosphate (FdUMP) by
thymidine kinase. 5-Fluoro-2ʹ-… Cellular uptake of gemcitabine is largely mediated by hENT …

… nucleosides to generate thymidine monophosphate. This reaction belongs to the pyrimidine
… activity with DNA synthesis, assessed by 3 H-thymidine uptake, in maize embryo axes. (B) …

… After cellular uptake, nucleoside analogues must be … of cellular kinases, nucleoside
phosphorylation is often the limiting step of metabolic incorporation. (14,15) Fluorescent nucleoside …

… We then asked whether knockdown of other nucleotide kinases (such as deoxycytidine
kinase, … Thus, another nucleotide kinase, DCK that similar to TK1 induces DNA damage when …