Metabolically activated adipose tissue macrophages link obesity to triple-negative breast cancer

P Tiwari, A Blank, C Cui, KQ Schoenfelt… - Journal of Experimental …, 2019 - rupress.org
Obesity is associated with increased incidence and severity of triple-negative breast cancer
(… Here, we show that obesity reprograms mammary adipose tissue macrophages to a pro-…

[HTML][HTML] The impact of adipose tissue–derived miRNAs in metabolic syndrome, obesity, and cancer

GS Heyn, LH Corrêa, KG Magalhães - Frontiers in endocrinology, 2020 - frontiersin.org
tissue macrophages from lean and obese mice, showing that the M1 macrophages were
prevalent in adipose tissue from obese … , in adipose tissue from lean mice, macrophages mostly …

The obese adipose tissue microenvironment in cancer development and progression

DF Quail, AJ Dannenberg - Nature Reviews Endocrinology, 2019 - nature.com
… Interestingly, in preclinical models of breast cancer, tumour-associated macrophages
tissue macrophages 59 . The population of CD11c + macrophages accelerates breast cancer

[HTML][HTML] The effect of adipocyte–macrophage crosstalk in obesity-related breast cancer

AB Engin, A Engin, II Gonul - Journal of molecular …, 2019 - jme.bioscientifica.com
… pathway activity due to increases in number of adipose tissue macrophages (ATMs) are
important contributing factors to the pathogenesis of obesity-related diseases. Eventually, these …

[HTML][HTML] The interplay between tissue niche and macrophage cellular metabolism in obesity

S Daemen, JD Schilling - Frontiers in immunology, 2020 - frontiersin.org
… Modulation of obesity and metabolic disorders by tissue macrophages. Tissue macrophages
can affect obesity and the development of associated metabolic disorders by affecting …

[HTML][HTML] Obesity-associated extracellular matrix remodeling promotes a macrophage phenotype similar to tumor-associated macrophages

NL Springer, NM Iyengar, R Bareja, A Verma… - The American Journal of …, 2019 - Elsevier
… The recognition of anti-inflammatory macrophages and up-regulated cancer-related pathways
in obese adipose tissue macrophages spans the past decade.25, 26 Indeed, similar to our …

[HTML][HTML] Tissue immune cells fuel obesity-associated inflammation in adipose tissue and beyond

R Liu, BS Nikolajczyk - Frontiers in immunology, 2019 - frontiersin.org
… Herein we discuss immune cell functions in various tissues and obesity-associated
cancers from the viewpoint of inflammation. We also emphasize recent advances in the …

Adipose tissue macrophage phenotypes and characteristics: the key to insulin resistance in obesity and metabolic disorders

Y Ni, L Ni, F Zhuge, L Xu, Z Fu, T Ota - Obesity, 2020 - Wiley Online Library
… , were shown to be effective for obesity-induced IR and other … of macrophages in adipose
tissue under conditions of obesitymacrophages might be a key therapeutic target for obesity-…

[HTML][HTML] Obesity and breast cancer: a case of inflamed adipose tissue

R Kolb, W Zhang - Cancers, 2020 - mdpi.com
obesity and breast cancer. The aim of this review is to highlight the association between obesity
and breast cancer and … is due to chronic adipose tissue inflammation. We will discuss the …

[HTML][HTML] Metabolism of tissue macrophages in homeostasis and pathology

SK Wculek, G Dunphy, I Heras-Murillo… - Cellular & molecular …, 2022 - nature.com
… as metabolic syndrome, atherosclerosis, fibrosis or cancer. … We focus on macrophages
that have been studied in vivo with … In addition, while the metabolism of tissue macrophages