Sensitivity of transcription factors to DNA methylation

É Héberlé, AF Bardet - Essays in biochemistry, 2019 - portlandpress.com
… Although DNA methylation has long been thought to repress TF binding, a more recent …
inhibit DNA methylation. Here, we review the possible scenarios by which DNA methylation and …

[HTML][HTML] Toward a mechanistic understanding of DNA methylation readout by transcription factors

JF Kribelbauer, XJ Lu, R Rohs, RS Mann… - Journal of molecular …, 2020 - Elsevier
… was observed, namely that DNA methylation can actively block the binding of the
transcription factor NRF1 [17], again underscoring that DNA methylation can have a biologically …

DNMTs and impact of CpG content, transcription factors, consensus motifs, lncRNAs, and histone marks on DNA methylation

J Loaeza-Loaeza, AS Beltran, D Hernández-Sotelo - Genes, 2020 - mdpi.com
factors (TF) binding sites, lncRNAs, and histone marks to regulate DNA methylation. We also
review how complexes of DNMTs/TFs or DNMTs/lncRNAs are involved in DNA methylation

DNA methylation repels binding of hypoxia-inducible transcription factors to maintain tumor immunotolerance

F D'anna, L Van Dyck, J Xiong, H Zhao, RV Berrens… - Genome biology, 2020 - Springer
… expression of cryptic transcripts. In line with such cryptic transcripts being more prone to
cause double-stranded RNA and viral mimicry, we observe low DNA methylation and high …

A DNA Methylation Reader–Chaperone Regulator–Transcription Factor Complex Activates OsHKT1;5 Expression during Salinity Stress

J Wang, N Nan, N Li, Y Liu, TJ Wang, I Hwang, B Liu… - Plant Cell, 2020 - academic.oup.com
… (a MYB transcription factor) and OsSUVH7 (a DNA methylation reader), … transcriptional
complex, consisting of a DNA methylation reader, a chaperone regulator, and a transcription factor

DNA methylation as a transcriptional regulator of the immune system

L Morales-Nebreda, FS McLafferty, BD Singer - Translational Research, 2019 - Elsevier
… , and certain transcription factors, acts as readers of methylation marks to link DNA
methylation and gene expression changes.7, 8 Alterations to the DNA methylation maintenance …

DNA methylation disruption reshapes the hematopoietic differentiation landscape

F Izzo, SC Lee, A Poran, R Chaligne, F Gaiti, B Gross… - Nature …, 2020 - nature.com
… in support of differential sensitivity of transcription factors due to biases in CpG enrichment
in … in CpG density of DNA-binding motifs of cell-fate-specific transcription factors may lead to …

Widespread effects of DNA methylation and intra-motif dependencies revealed by novel transcription factor binding models

J Grau, F Schmidt, MH Schulz - Nucleic Acids Research, 2023 - academic.oup.com
… motif analysis that combines information about DNA methylation with models capturing intra-…
with DNA methylation. Overall, we find that the presence of CpG methylation decreases the …

CG dinucleotides enhance promoter activity independent of DNA methylation

D Hartl, AR Krebs, RS Grand, T Baubec, L Isbel… - Genome …, 2019 - genome.cshlp.org
… contribution of CpGs to transcriptional activity and binding of transcription factors to their motifs
in … reveal that CpGs contribute to transcriptional output independent of DNA methylation. …

The role of DNA methylation in genome-wide gene regulation during development

H Cedar, O Sabag, Y Reizel - Development, 2022 - journals.biologists.com
transcription factors acting directly on the promoter that constitutes the rate-limiting component
of gene activation. Indeed, RNA analysis has shown that the expression levels of these …