Distinct immune composition in lymph node and peripheral blood of CLL patients is reshaped during venetoclax treatment
I de Weerdt, T Hofland, R de Boer, JA Dobber… - Blood …, 2019 - ashpublications.org
… untreated CLL patients, and by analyzing the effects of venetoclax-based treatment regimens
on … from previously untreated and relapsed/refractory patients. CLL-derived LNs contained …
on … from previously untreated and relapsed/refractory patients. CLL-derived LNs contained …
Body composition and sarcopenia: the next-generation of personalized oncology and pharmacology?
M Hilmi, A Jouinot, R Burns, F Pigneur… - Pharmacology & …, 2019 - Elsevier
Body composition has gained increasing attention in oncology in recent years due to fact
that sarcopenia has been revealed to be a strong prognostic indicator for survival across …
that sarcopenia has been revealed to be a strong prognostic indicator for survival across …
Predictable modulation of cancer treatment outcomes by the gut microbiota
… composition between R and NR in our cohort, we examined whether statistical modeling
would enable prediction of treatment response … more confounding regimens to demonstrate the …
would enable prediction of treatment response … more confounding regimens to demonstrate the …
A cellular hierarchy framework for understanding heterogeneity and predicting drug response in acute myeloid leukemia
… patients. Without measuring these cellular hierarchies at scale in large clinical datasets, the
relationship of hierarchy composition to therapy response … of combination regimens through …
relationship of hierarchy composition to therapy response … of combination regimens through …
Modulating the microbiome to improve therapeutic response in cancer
JL McQuade, CR Daniel, BA Helmink… - The Lancet …, 2019 - thelancet.com
… treatment to improve outcomes. In this Review, we examine the evidence on the role of the
microbiome in cancer and therapeutic response, … Notably, the composition of these other …
microbiome in cancer and therapeutic response, … Notably, the composition of these other …
[HTML][HTML] … maintenance lenalidomide and depth of response on the genetics and sub-clonal structure of relapsed disease in uniformly treated newly diagnosed patients
… We believe this work supports the current best practice strategy of using different treatment
regimens at successive relapses and shows why this approach is successful. We show that …
regimens at successive relapses and shows why this approach is successful. We show that …
[HTML][HTML] Redefining breast cancer subtypes to guide treatment prioritization and maximize response: Predictive biomarkers across 10 cancer therapies
DM Wolf, C Yau, J Wulfkuhle, L Brown-Swigart… - Cancer Cell, 2022 - cell.com
… ) status to better predict drug responses. We assess the predictive … patients treated with 10
regimens targeting diverse biology. We explore >11 subtyping schemas and identify treatment…
regimens targeting diverse biology. We explore >11 subtyping schemas and identify treatment…
Standardised shorter regimens versus individualised longer regimens for rifampin-or multidrug-resistant tuberculosis
… to those using either moxifloxacin or levofloxacin (as gatifloxacin is no longer available)
and we restricted longer regimens to those whose composition met 2018 WHO guidelines by …
and we restricted longer regimens to those whose composition met 2018 WHO guidelines by …
Peripheral blood TCR repertoire profiling may facilitate patient stratification for immunotherapy against melanoma
SA Hogan, A Courtier, PF Cheng… - Cancer immunology …, 2019 - AACR
… No predictive biomarker for patient stratification prior to treatment other than routine PD-L1 …
However, our analysis does not allow us to determine the exact composition of the TCR …
However, our analysis does not allow us to determine the exact composition of the TCR …
The relationship between imaging-based body composition analysis and the systemic inflammatory response in patients with cancer: a systematic review
… routine use in cancer staging, CT has become the preferred standard for measuring body
composition… review and to provide the best patient care. Moreover, how an algorithm could be …
composition… review and to provide the best patient care. Moreover, how an algorithm could be …
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