Auricular vagal nerve stimulation improves constipation by enhancing colon motility via the central-vagal efferent pathway in opioid-induced constipated rats

Y Zhang, T Lu, Y Meng, A Maisiyiti, Y Dong, S Li… - … : Technology at the …, 2021 - Elsevier
Objectives Constipation and opioid-induced constipation (OIC) are common with limited
treatment options. We investigated whether a noninvasive method of auricular vagal nerve …

Role of the sympathetic nervous system in cardiometabolic control: implications for targeted multiorgan neuromodulation approaches

R Carnagarin, MG Kiuchi, G Goh, L Adams… - Journal of …, 2021 - journals.lww.com
… Diet-induced and exercise-induced weight loss remains a key … the right abdominal branch
of the vagus, then forms a network … α-receptor blockade with prazosin and β-receptor blockade

Blood glucose modulation and safety of efferent vagus nerve stimulation in a type 2 diabetic rat model

SC Payne, G Ward, JB Fallon, T Hyakumura… - Physiological …, 2022 - Wiley Online Library
… type 1 diabetic symptoms (eg, sudden weight loss). As a secondary qualitative indicator of
the … rat (not used in this study) during no block (224 µA threshold) and during 26 kHz blocking …

[HTML][HTML] Do gut hormones contribute to weight loss and glycaemic outcomes after bariatric surgery?

D Papamargaritis, CW le Roux - Nutrients, 2021 - mdpi.com
… enough weight loss to reverse complications and weight loss … add a further weight loss of
2.6–8.8% [8] and help with weight … A subsequent study accordingly tried to block both GLP-1 …

Early benefits of bariatric surgery on subclinical cardiac function: contribution of visceral fat mobilization

ME Piché, MA Clavel, A Auclair, M Rodríguez-Flores… - Metabolism, 2021 - Elsevier
… The percentage of total weight loss at 6 months after bariatric … association was found with
weight loss or change in insulin … Sympatho-vagal balance was defined as the ratio of low …

[HTML][HTML] Vagally mediated gut-brain relationships in appetite control-insights from porcine studies

CH Malbert - Nutrients, 2021 - mdpi.com
weight loss [83]. Based … vagal blockade has been developed to generate weight loss. Not
surprisingly, reflecting the extreme intricacy, even in vitro, of achieving effective nerve blockade

[HTML][HTML] Autonomic nervous system activity changes in patients with hypertension and overweight: role and therapeutic implications

P Valensi - Cardiovascular diabetology, 2021 - Springer
… In addition to sympathetic alterations, a cardiac vagal defect may be detected in more than …
when used as part of a weight-loss program [38]. Additionally, weight loss has been shown to …

Cardiac remodeling in obesity and after bariatric and metabolic surgery; is there a role for gastro-intestinal hormones?

E Sanches, M Timmermans, B Topal… - Expert review of …, 2019 - Taylor & Francis
… achieve significant excess weight loss. This … weight loss, whereas gut hormonal blockade
by antibodies or pharmacological agents (such as octreotide) can diminish the weight loss

The altered enteroendocrine reportoire following roux-en-Y-gastric bypass as an effector of weight loss and improved glycaemic control

RC Moffett, NG Docherty, CW le Roux - Appetite, 2021 - Elsevier
… Bariatric surgery is by a substantial margin, the most efficacious means of achieving
sustained weight loss maintenance in patients with obesity. Roux-en-Y gastric bypass surgery (…

[HTML][HTML] How should we think about the unprecedented weight loss efficacy of incretin-mimetic drugs?

Y Gou, MW Schwartz - The Journal of Clinical Investigation, 2023 - Am Soc Clin Investig
… Ingested nutrients also activate afferent vagal and somatosensory nerves that innervate the
… s starting weight, it makes sense to develop weight loss therapeutics that block this response …