A guide to plasma membrane solute carrier proteins

MD Pizzagalli, A Bensimon… - The FEBS …, 2021 - Wiley Online Library
… an introduction to the solute carrier proteins (SLC) superfamily of transporter proteins and
their roles in human cells. The SLC superfamily currently includes 458 transport proteins in 65 …

[HTML][HTML] An overview of cell-based assay platforms for the solute carrier family of transporters

V Dvorak, T Wiedmer, A Ingles-Prieto… - Frontiers in …, 2021 - frontiersin.org
… For each SLC, the localization at the plasma membrane, the electrogenicity and the main
substrate class are annotated. Annotation information regarding localization and substrate was …

[HTML][HTML] Systematic in silico discovery of novel solute carrier-like proteins from proteomes

G Gyimesi, MA Hediger - PLoS One, 2022 - journals.plos.org
… In this regard, we believe that our work provides correlation between transporter proteins in
… , it is localized to both the plasma membrane and intracellular membrane compartments [64]. …

[HTML][HTML] A structure and evolutionary-based classification of solute carriers

E Ferrada, G Superti-Furga - Iscience, 2022 - cell.com
… gene member of the nucleoside-sugar transport familycell membrane at rates required
by cellular physiology, organisms have evolved membrane proteins that facilitate the transport

New and emerging research on solute carrier and ATP binding cassette transporters in drug discovery and development: outlook from the international transporter …

KM Giacomini, SW Yee, ML Koleske… - Clinical …, 2022 - Wiley Online Library
… on the plasma membrane. … of transporter protein expression levels in key ADME-related
organs, such as the intestines, liver, and kidneys followed by a short description of transporter

Emerging roles of the human solute carrier 22 family

SW Yee, KM Giacomini - Drug Metabolism and Disposition, 2022 - ASPET
… organic ion transporter family, consists of 28 distinct multi-membrane spanning proteins, which
… that function to move substrates across the plasma membrane by one of the mechanisms (…

[HTML][HTML] Substrate specificities and inhibition pattern of the solute carrier family 10 members NTCP, ASBT and SOAT

G Grosser, SF Müller, M Kirstgen, B Döring… - Frontiers in molecular …, 2021 - frontiersin.org
… Three carriers of the solute carrier family SLC10 have been functionally characterized so
far. Na + /taurocholate cotransporting polypeptide NTCP is a hepatic bile acid transporter and …

Solute carrier transporters as potential targets for the treatment of metabolic disease

T Schumann, J König, C Henke, DM Willmes… - Pharmacological …, 2020 - ASPET
The solute carrier (SLC) superfamily comprises more than 400 transport proteins mediating …
ions, nucleotides, and sugars across biological membranes. Over 80 SLC transporters have …

The concise guide to pharmacology 2021/22: Transporters

SPH Alexander, E Kelly, A Mathie… - British Journal of …, 2021 - Wiley Online Library
… Within the solute carrier family, there are a great variety of solutes transported, from simple
plasma membrane, or solute transport into and out of cellular organelles. Some SLC family

A substrate‐based ontology for human solute carriers

E Meixner, U Goldmann, V Sedlyarov… - Molecular Systems …, 2020 - embopress.org
membranes, as well as the plasma membrane. We found that nearly two-thirds of annotated
SLCs have been reported to be localized, at least partially, on the plasma membrane. The …