[HTML][HTML] Advances and gaps in SARS-CoV-2 infection models

C Muñoz-Fontela, L Widerspick, RA Albrecht… - PLoS …, 2022 - journals.plos.org
… are susceptible to certain SARS-CoV-2 VOCs, specifically to the … animal model of asymptomatic
infection with SARS-CoV-2, … models than other VOCs. This raises the possibility that …

[HTML][HTML] SARS-CoV-2 pandemic and research gaps: Understanding SARS-CoV-2 interaction with the ACE2 receptor and implications for therapy

PK Datta, F Liu, T Fischer, J Rappaport, X Qin - Theranostics, 2020 - ncbi.nlm.nih.gov
… view of ACE2 in the pathogenesis of SARS-CoV-2 infection. … , we will review animal models
for both SARS and COVID-19. … therapeutic and vaccine developments related to blocking …

[HTML][HTML] Animal models for COVID-19: advances, gaps and perspectives

C Fan, Y Wu, X Rui, Y Yang, C Ling, S Liu… - Signal transduction and …, 2022 - nature.com
… to develop animal models of SARS-CoV-2 infection as … models, as well as the classical
and alternative SARS-CoV-2 receptors and proteases. Then, the gaps in current animal models

SARS-CoV-2/COVID-19: evolving reality, global response, knowledge gaps, and opportunities

MF Osuchowski, F Aletti, JM Cavaillon, SB Flohe… - Shock, 2020 - journals.lww.com
… initially present with an asymptomatic infection subsequently progress into clinical disease.
… emerging COVID-19 models. While modeling of SARS-CoV-2 infection in healthy and young …

[HTML][HTML] Recent advances in pathophysiology, drug development and future perspectives of SARS-CoV-2

DD Singh, I Han, EH Choi, DK Yadav - Frontiers in cell and …, 2020 - frontiersin.org
… as other developments for dealing with SARS-CoV-2 infection. A … Like any other disease
model, the forecast of SARS-CoV-2 … To avoid research gaps in SARS-CoV-2, clinical, and public …

[HTML][HTML] Mucosal vaccines for SARS-CoV-2: scientific gaps and opportunities—workshop report

JM Knisely, LE Buyon, R Mandt, R Farkas… - npj Vaccines, 2023 - nature.com
… We also provide recommendations to advance the field and accelerate the development of …
body of work on SARS-CoV-2 infection and vaccination in both animal models and humans is …

[HTML][HTML] Bridging animal and clinical research during SARS-CoV-2 pandemic: A new-old challenge

MS Winkler, T Skirecki, FM Brunkhorst, S Cajander… - …, 2021 - thelancet.com
… The SARS-CoV-2 pandemic has evoked a tremendous … However, several animal
SARS-CoV-2/COVID-19 models have been … WT mice are resistant to SARS-CoV-2 infection as the …

[HTML][HTML] Evidence of a wide gap between COVID-19 in humans and animal models: a systematic review

SN Ehaideb, ML Abdullah, B Abuyassin, A Bouchama - Critical Care, 2020 - Springer
… COVID-19 can progress to acute respiratory distress syndrome (ARDS), multiple … SARS-CoV-2
infection. Several candidate DNA vaccines based in various forms of the SARS-CoV-2

SARSCoV2: Mechanism of infection and emerging technologies for future prospects

S Li, S Li, C Disoma, R Zheng, M Zhou… - Reviews in Medical …, 2021 - Wiley Online Library
… the molecular model of related viral proteins. The catalytic sites of four enzymes of … progress
of SARS-CoV-2 and synthesized the rapidly growing literature to identify knowledge gaps. …

Bioengineered in Vitro Tissue Models to Study SARS-CoV-2 Pathogenesis and Therapeutic Validation

J Chakraborty, I Banerjee, R Vaishya… - … biomaterials science & …, 2020 - ACS Publications
progress in modeling SARS-CoV-2 infection in animal … model for rapid assessment of
infection by SARS-CoV-2. … When the gap between the “bench” and the “bedside” is bridged, …