… of S100A4, respectively, attenuated pulmonary fibrosis in the bleomycin mouse model.16,
17 Our results suggest that IPF patients with elevated serum S100A4 levels represent a …

論文の内容の要旨 [はじめに] 特発性肺線維症 (IPF) は, 肺の不可逆的な線維化を特徴とする予後
不良な間質性肺疾患 (ILD) である. 抗線維化薬は重要な治療選択肢であり, 予後改善のためには, …

… pathogenic mechanism of idiopathic pulmonary fibrosis (IPF). S100 calcium-binding protein
A4 (S100A4) … However, the clinical implications of S100A4 in IPF have not been evaluated. …

… Third, little is known about the value of S100A4 in clinical practice. Hence, future studies should
enlarge the sample size to explore the clinical significance … Idiopathic pulmonary fibrosis …

… Interstitial pneumonia (IP), mostly idiopathic pulmonary fibrosis (IPF), is associated with an
… , serum S100A4 level was a significant predictive factor for AE of IP. This will help clinicians …

… Clinical significance of serum S100 calcium-binding protein A4 in idiopathic pulmonary
fibrosis… A multidimensional index and staging system for idiopathic pulmonary fibrosis. Ann. Intern…

… S100 protein family, which represents 25 relatively small calcium binding proteins, is involved
in many intracellular and/or extracellular processes, … IPF idiopathic pulmonary fibrosis …

… S100A4 is a member of the S100 calcium-binding protein … in the serum of patients with
idiopathic pulmonary fibrosis [15]. … A4 in idiopathic pulmonary fibrosis,” Respirology, vol. 25, no. …

… S100 calcium-binding protein A4 (S100A4, fibroblast-specific … [153] have shown the clinical
significance of serum S100A4 … S100 family of calcium-binding proteins that has a significant …

… 10-14kDa), acidic, and calciumbinding proteins (CaBPs) with two … In addition to its role in
idiopathic pulmonary fibrosis (IPF), … Zhen, “The expression of S100B protein in serum of patients …