… Epidemiology of Diabetes Interventions and Complications (… the involvement of epigenetic
DNA methylation (DNAme) in … , and with subsequent development of complications over an …

… in type 1 diabetes through its role in SLC2A1/glucose transporter 1-mediated glucose … We
assessed whether HbA1c-associated CpGs were associated with other clinical characteristics …

… (EDIC) [6] and the Pittsburgh Epidemiology of Diabetes Complications (EDC) study [7]. In
DCCT/EDIC, methylation at HbA1c-associated CpG sites explained much of the statistical …

… Most DNA methylation occurs in a CpG dinucleotide context [… mediated through the family
of ten-eleven translocase enzymes [19]. DNA methylation is essential for normal development, …

… that hyperglycemia directly affects DNA methylation before the onset of diabetes-related …
DNA methylation mediates development of HbA1c-associated complications in type 1 diabetes. …

… Diabetes Interventions and Complications study, the investigators found DNAm at HbA1c-associated …
of small molecules, vesicle-mediated transport, metabolism, signal transduction, …

… with the development of diabetes complications. We observe reduced DNA methylation of
the … (podocytes and proximal convoluted tubule) assessed for DNA methylation mediated …

… We identi ed that longitudinal DNA methylation changes at … determine statistically signi cant
HbA1c associated CpGs (hDMCs… of diabetic complications, such as “small GTPase mediated …

… mediate environmental influences on aberrant gene expression. … for each of the identified
HbA1c associated DNAm loci. … genetic variation can confound DNA methylation status, we …

… CpGs on risk of KF were mediated through at least one KF-associated circulating protein (…
words the effects mediated by the circulating proteins represented as percent mediated (PM)…