… a cell cycle description. Here, we derive a theory describing how messenger RNA (mRNA) …
influenced by stochasticity in the duration of the cell cycle and the timing of DNA replication. …

… measurements of mRNA flow across the cell. We developed subcellular TimeLapse-seq to
measure the rates at which RNAs … cytoplasm in human and mouse cells. These rates varied …

… a given gene per cell is variable between cells in a population ( … abundance variation for
most genes (Figure 1C). Moreover, mean … We also measured total RNA abundance using RNA …

… the lineage-primed clusters composed of low-abundant HSPCs … our computational cell cycle
classification that lineage-primed … with cell to cell variations due to cell cycle effect regressed …

… noncoding RNA throughout essential processes, such as cell cycle and lineage commitment
… that short, less abundant molecules, such as miRNAs (35), can be size-selected from a UMI-…

… time and cell fate potential by analyzing a lineage tracing … , the relative abundance of these
cells ranged from 0.008% to … neighborhood-wide variability in cell cycle gene expression …

… leads to varied messenger RNA (mRNA) abundances for each … TF mRNA heterogeneity
across steady-state cell populations… correlations are measured—eg, at least one cell division. […

… transcription measurements of the same gene. We find that: (i) correcting for cell cycle …
likelihood of observing the single cell mature mRNA numbers measured in a population of …

… Here, we measure and analyze cell cycles in deep lineage … that control duration and variability
of the cell cycle. … MYCN-inhibited populations were established by incubating cells with 1 …

… track the mRNA statistics over time along a single-cell lineage, … per cell cycle phase do not
scale with cell cycle progression (… cell size and age variability from technical noise effects on …