GlgA plays an important role in the induction of hydrosalpinx by Chlamydia muridarum

C Hu, H Wu, Y Sun, J Kong, LL Shao… - Pathogens and …, 2020 - academic.oup.com
… of GlgA deficiency on hydrosalpinx induction in mice. We selected two C. muridarum strains
with GlgAmuridarum. The two mutant isolates had different site mutations that would lead to …

Tryptophan residue of plasmid-encoded Pgp3 is important for Chlamydia muridarum to induce hydrosalpinx in mice

Y Huang, H Wu, Y Sun, Y Liu - Frontiers in Microbiology, 2023 - frontiersin.org
… Pgp3 and GlgA protein expression … GlgA expression (Figure 2). However, although Pgp3
immunoactivity was detected in cultures infected with Pgp3Y197A or Pgp3W234A C. muridarum

A chlamydial plasmid-dependent secretion system for the delivery of virulence factors to the host cytosol

L Lei, C Yang, MJ Patton, M Smelkinson, D Dorward… - Mbio, 2021 - Am Soc Microbiol
role of GlgA in chlamydial pathogenesis remains poorly defined, nonisogenic Chlamydia
muridarum strains with GlgA … Expression of GlgA/His fusion protein was induced with isopropyl-…

Identification of HeLa cell proteins that interact with Chlamydia trachomatis glycogen synthase using yeast two‑hybrid assays

Z Sun, Y Sun, Y Li, X Luan, H Chen… - Molecular …, 2020 - spandidos-publications.com
… genital tract can result in tubal fibrosis and hydrosalpinx. Therefore, the aim of the present
… whether GlgA secretion into the host cell cytosol is necessary for the induction of chlamydial

Co-ordinated regulation of pathways controlling chlamydial virulence and stress response

SY Omesi - 2021 - cdr.lib.unc.edu
… served a regulatory role in the expression of pgp3 and glgA, … deficient strain of C.muridarum
was associated with a highly … is associated with failure to induce hydrosalpinx, a condition …

Chlamydia trachomatis glycogen synthase promotes MAPK-mediated proinflammatory cytokine production via TLR2/TLR4 in THP-1 cells

Z Sun, Y Li, H Chen, L Xie, J Xiao, X Luan, B Peng, Z Li… - Life sciences, 2021 - Elsevier
chlamydial component GlgA is secreted into host cells, we sought to determine whether GlgA
is capable of inducing … A recent study showed that GlgA deficiency reduced hydrosalpinx

[HTML][HTML] Plasmid-mediated virulence in Chlamydia

BJ Turman, T Darville, CM O'Connell - Frontiers in Cellular and …, 2023 - ncbi.nlm.nih.gov
… to immune responses induced by chlamydial infection at these … The absence of Pgp4
and consequent reduced glgAmuridarum developed hydrosalpinx compared to 80% for …

Efficacy of Pgp3 vaccination for Chlamydia urogenital tract infection depends on its native conformation

B Peng, S Zhong, Y Hua, Q Luo, W Dong… - Frontiers in …, 2022 - frontiersin.org
muridarum vaginal infection induces hydrosalpinx in mice, similar to female fallopian tube …
in chlamydial pathogenesis since Pgp3-deficient C. muridarum failed to induce hydrosalpinx

Chlamydia trachomatis plasmid gene protein 3 is essential for the establishment of persistent infection and associated immunopathology

C Yang, L Kari, L Lei, JH Carlson, L Ma, CE Couch… - MBio, 2020 - Am Soc Microbiol
… chromosomal genes, including GlgA, CT049-CT050, … significant reduction in shedding
duration in the ocular trachoma model (17), leading to the hypothesis that the plasmid plays a role

Can't live outside you: a thematic issue on obligate intracellular bacterial pathogens

J Coers, HJ Newton, JA Carlyon - Pathogens and Disease, 2021 - academic.oup.com
… ubiquitous swine pathogen Chlamydia suis provide insights into evolutionary dynamics of
the Chlamydia genus and identify gene sets specific to certain Chlamydia species as potential …