Physiological models for in vivo imaging and targeting the lymphatic system: Nanoparticles and extracellular vesicles

D Olmeda, D Cerezo-Wallis, E Castellano-Sanz… - Advanced Drug Delivery …, 2021 - Elsevier
… Therefore, there is great interest in visualizing the lymphatic vasculature in vivo. Here, we
review imaging tools and mouse models used to analyze the lymphatic vasculature during …

Overcoming physiological barriers by nanoparticles for intravenous drug delivery to the lymph nodes

N Trac, EJ Chung - Experimental Biology and Medicine, 2021 - journals.sagepub.com
… to have phagocytic capacity and affect nanoparticle clearance in vivo. Macrophages can be
physiological barriers described in this section, nanoparticles can enter the lymphatic system

Nanoparticle-based approaches to target the lymphatic system for antitumor treatment

X Peng, J Wang, F Zhou, Q Liu, Z Zhang - Cellular and Molecular Life …, 2021 - Springer
… NPs and adopting various administration routes to facilitate lymphatic system uptake [20].
In addition, nanoparticle self-assembly in vivo has been employed for sustained drug delivery …

Lymphatic targeting for therapeutic application using nanoparticulate systems

N Singh, M Handa, V Singh, P Kesharwani… - … of Drug Targeting, 2022 - Taylor & Francis
… evaluating in vivo distribution characteristics or lymphatic delivery of … delivery of the
nanoparticle in lymphatic system. Irrespective … Normal physiological features of lymphatic system

Targeting lymphatics for nanoparticle drug delivery

J McCright, R Naiknavare, J Yarmovsky… - Frontiers in …, 2022 - frontiersin.org
… In this review, we discuss the physiology of lymphatic vessels and mechanisms used in the
… formulations reached lymph nodes and were more effective in elucidating in-vivo immune …

Therapeutic delivery to the brain via the lymphatic vasculature

P Zhao, Z Le, L Liu, Y Chen - Nano Letters, 2020 - ACS Publications
… (ICG)-loaded PLGA nanoparticles as a model, we show that … a high colloidal stability in
physiological medium due to the … that nanoparticles can diffuse through the lymphatic vessels

Simulation of the in vivo fate of polymeric nanoparticles traced by environment-responsive near-infrared dye: A physiologically based pharmacokinetic modelling …

L Li, H He, S Jiang, J Qi, Y Lu, N Ding, HS Lin, W Wu… - Molecules, 2021 - mdpi.com
… , owing to the complicated in vivo transport mechanisms involving nanoparticles, including
… , lymphatic transport, and changes in physical properties. In our study, five nanoparticle

[HTML][HTML] Imaging technology of the lymphatic system

AK Polomska, ST Proulx - Advanced drug delivery reviews, 2021 - Elsevier
… of basic anatomy and physiology and in our understanding of … In vivo imaging of the lymphatic
system in animal models has … The optimal size of nanoparticles for SLN imaging was found …

The bright future of nanotechnology in lymphatic system imaging and imaging-guided surgery

S Qi, X Wang, K Chang, W Shen, G Yu, J Du - Journal of …, 2022 - Springer
… and NIR imaging in vivo after dorsal foot injection of PL(I/D)NPs. b Representative fluorescence
and 3D reconstructed CT images of superficial lymphatics with PL(I/D)NPs in vivo after …

Nano lipid based carriers for lymphatic voyage of anti-cancer drugs: An insight into the in-vitro, ex-vivo, in-situ and in-vivo study models

S Chaturvedi, A Garg, A Verma - Journal of Drug Delivery Science and …, 2020 - Elsevier
… The flow of lymph from the lymphatic vessels is unidirectional … Hence, the lipid nanoparticles
with particle size in the range … simulate in-vivo physiological conditions [112]. Now, this …