… to identify novel antimelanogenic drugs from an epigenetic … to screen an epigenetic
drug library to identify new drug … Of 141 total drugs tested in this study, drugs H4 (N-hydroxy-3-…

… shown to inhibit tyrosinase (TYR) catalytic activity or downregulate … by genetic or epigenetic
variations, as in the cases of … the discovery of peptide drugs because several amino acids …

… identify drug candidates that can promote melanin synthesis in cells, we screened an epigenetic
modulator library … increased intracellular melanin content and tyrosinase (TYR) activity. …

… Hir suppressed melanin synthesis by dual inhibition of tyrosinase activity and … screened
approximately 130 crude drugs used in Kampo formulas and 250 natural compounds to identify …

… which occur due to unregulated melanin biosynthesis and/or … Consequently, certain antidiabetic
drugs such as voglibose [… -308 might inhibit activity of the enzyme tyrosinase, as well as …

… discussed as a promising target for vitiligo drug development. … Several bioactive compounds
have been identified in ginger, … Tyrosinase is well known as the key enzyme in melanin …

… of the growing areas in modern drug discovery. With this aim, … Among the FA hybrids, we
have identified the good ability of … and a moderate activity as inhibitor of Aβ aggregation [56], …

… Pep1-induced ROS production and root growth inhibition, we … However, interfering with auxin
or ROS signaling separately … The double and triple mutants were identified by PCR and RT…

… In the present study, however, we did not identify the … epigenetic regulation to gene
expression in muscle tissues. … in lysis buffer containing a protease inhibitor cocktail. The protein …