The role of epithelial cells in the immunopathogenesis of Sjögren's syndrome

Y Tang, Y Zhou, X Wang, N Che, J Tian… - Journal of Leukocyte …, 2024 - academic.oup.com
… and tissue destruction in Sjögren’s syndrome. Herein, we reviewed recent advances in …
the role of salivary gland epithelial cells in the pathogenesis of Sjögren’s syndrome, which …

The role of stroma and epithelial cells in primary Sjögren's syndrome

S Asam, G Neag, O Berardicurti, D Gardner… - …, 2021 - academic.oup.com
… This review summarizes the current knowledge about the role of stromal cells (including
endothelium, epithelium, … The role of epithelial cells in the pathogenesis of Sjögren’s syndrome

Epithelial–immune cell interplay in primary Sjögren syndrome salivary gland pathogenesis

GM Verstappen, S Pringle, H Bootsma… - Nature Reviews …, 2021 - nature.com
… Primary Sjögren syndrome (pSS) typically refers to the occurrence of Sjögren syndrome as
the … We focus on new insights into the development of abnormalities in epithelial cells, as well …

[PDF][PDF] Pathogenesis of primary Sjögren's syndrome beyond B lymphocytes

S Fasano, D Mauro, F Macaluso, F Xiao… - Clin Exp …, 2020 - clinexprheumatol.org
Pathogenesis of primary Sjögren’s syndrome. Environmental factors such as virus may trigger
the activation of salivary gland epithelial cells … primary Sjögren syndrome: comparison with …

Emerging roles for chemokines and cytokines as orchestrators of immunopathology in Sjögren's syndrome

SLM Blokland, CM Flessa, JAG van Roon… - …, 2021 - academic.oup.com
… such as saliva and serum, salivary gland (SG) tissue (SGT) and secretome (SG biopsy … SG
epithelial cells and Sjögren-like disease models in mice have shed light on the important role

Contributions of major cell populations to Sjögren's syndrome

R Witas, S Gupta, CQ Nguyen - Journal of clinical medicine, 2020 - mdpi.com
… This review will discuss the evidence for participation in disease pathogenesis by various
classes of immune cells and glandular epithelial cells based upon data from both preclinical …

Advances in pathogenesis of Sjögren's syndrome

Y Tian, H Yang, N Liu, Y Li… - Journal of immunology …, 2021 - Wiley Online Library
… anti-CD86 antibody improves the autoimmune damage to salivary and lacrimal glands,
indicating that these epithelial cells may have antigen-presenting functions and may increase T …

The multiple roles of B cells in the pathogenesis of Sjögren's syndrome

W Du, M Han, X Zhu, F Xiao, E Huang, N Che… - Frontiers in …, 2021 - frontiersin.org
… salivary gland epithelial cells (SGECs) and B cells may promote SS pathogenesis via
multiple effector mechanisms (119). It has been shown that SGECs can drive B cell activation, …

The role of interferons in the pathogenesis of Sjögren's syndrome and future therapeutic perspectives

N Del Papa, A Minniti, M Lorini, V Carbonelli… - Biomolecules, 2021 - mdpi.com
disease [45]. Specific type I-related transcript (IFIT-3) was mainly localized in salivary duct
epithelial cells, … and duct epithelial cells localized in the site of inflammatory cell infiltration [46]. …

Role of the innate immunity signaling pathway in the pathogenesis of Sjögren's syndrome

T Shimizu, H Nakamura, A Kawakami - International journal of molecular …, 2021 - mdpi.com
… and function in the salivary glands in SS, the enhancement of TLR7 expression in the minor
salivary glands was particularly evident in ductal epithelial cells, pDCs, and B cells in SS [66]…