Immunopathobiology and therapeutic targets related to cytokines in liver diseases

Y He, S Hwang, YA Ahmed, D Feng, N Li… - Cellular & molecular …, 2021 - nature.com
… Several cytokines have great therapeutic potential, and some are currently being tested as
therapeutic targets in clinical trials for the treatment of liver diseases, which are also described…

Immunological mechanisms and therapeutic targets of fatty liver diseases

H Wang, W Mehal, LE Nagy, Y Rotman - Cellular & Molecular …, 2021 - nature.com
cytokines to stimulate liver regeneration. Similarly, G-CSF improves the function of normal
and dysfunctional granulocytes, which also secrete cytokines to stimulate liver … against liver

Adipokines in non-alcoholic fatty liver disease: are we on the road toward new biomarkers and therapeutic targets?

V Francisco, MJ Sanz, JT Real, P Marques… - Biology, 2022 - mdpi.com
… Non-alcoholic fatty liver disease (NAFLD) is an unmet … clinical data on adipokines, cytokine-like
hormones secreted by … , as well as their potential as therapeutic targets for NAFLD. The …

Innate lymphocytes: pathogenesis and therapeutic targets of liver diseases and cancer

Y Chen, Z Tian - Cellular & molecular immunology, 2021 - nature.com
… virus infection, alcoholic liver disease, nonalcoholic fatty liver disease, autoimmune … of
hepatic innate lymphocytes will be helpful for proposing effective treatments for liver diseases and …

Neutrophils in liver diseases: pathogenesis and therapeutic targets

K Liu, FS Wang, R Xu - Cellular & molecular immunology, 2021 - nature.com
liver disease, liver fibrosis, cirrhosis, liver failure, and liver … review summarizes the role of
neutrophils in liver diseases. … During liver cirrhosis, high levels of proinflammatory cytokines

Matrix metalloproteinases as potential biomarkers and therapeutic targets in liver diseases

E Geervliet, R Bansal - Cells, 2020 - mdpi.com
… MMPs in liver diseases. MMP expression patterns in different stages of liver diseases have
also … , we highlight MMPs as promising therapeutic targets for the resolution of liver diseases. …

MicroRNAs as regulators, biomarkers and therapeutic targets in liver diseases

X Wang, Y He, B Mackowiak, B Gao - Gut, 2021 - gut.bmj.com
… the regulation and function of miRNAs in liver diseases with a major focus on miRNAs that
diseases and may identify biomarkers and therapeutic targets for liver diseases in the future…

Therapeutic targets, novel drugs, and delivery systems for diabetes associated NAFLD and liver fibrosis

V Kumar, X Xin, J Ma, C Tan, N Osna… - Advanced drug delivery …, 2021 - Elsevier
… targets for treating chronic liver diseases, including … liver and causes hepatocyte damage,
resulting in the activation of Kuffer cells (KCs) and the overproduction of inflammatory cytokines

The NLRP3 inflammasome in non-alcoholic fatty liver disease and steatohepatitis: Therapeutic targets and treatment

L Yu, W Hong, S Lu, Y Li, Y Guan, X Weng… - Frontiers in …, 2022 - frontiersin.org
… stress, promote inflammation, cell death, and progressive liver damage. These hits activate
inflammatory cascades and pro-inflammatory cytokines, including interleukin (IL)-1β, tumor …

Bile acids and their receptors: modulators and therapeutic targets in liver inflammation

A Bertolini, R Fiorotto, M Strazzabosco - Seminars in immunopathology, 2022 - Springer
… modulators of these pathways for the treatment of cholestatic and autoimmune liver diseases.
… Unlike in hepatocytes, bile acid–induced cytokine secretion was not observed in liver non-…