Impact of aging on animal models of Parkinson's disease
IH Klæstrup, MK Just, KL Holm, AKO Alstrup… - Frontiers in aging …, 2022 - frontiersin.org
… (PD), the second most common neurodegenerative disorder. Several animal models have
… , we provide recommendations to manage the challenges related to aged animal models. …
… , we provide recommendations to manage the challenges related to aged animal models. …
Intranasal delivery of bone marrow stromal cells preconditioned with Fasudil to treat a mouse model of Parkinson's disease
Y Tang, L Han, X Bai, X Liang, J Zhao… - … Disease and …, 2020 - Taylor & Francis
… This discrepancy between the two studies was perhaps due to different animal models and
… behavioural impairment, protect dopaminergic neurons in MPTP PD mice, and downregulate …
… behavioural impairment, protect dopaminergic neurons in MPTP PD mice, and downregulate …
Therapeutic Effect of Human Adipocyte-derived Stem Cell-derived Exosomes on a Transgenic Mouse Model of Parkinson's Disease
L Chan, W Hsu, KY Chen, W Wang, YC Hung, CT Hong - in vivo, 2023 - iv.iiarjournals.org
… represent a therapeutic cocktail for the rejuvenation of neurons undergoing age-related …
protection of repeated dosing of hADSC-derived exosomes in the transgenic PD mouse model…
protection of repeated dosing of hADSC-derived exosomes in the transgenic PD mouse model…
Progress towards therapies for disease modification in Parkinson's disease
N Vijiaratnam, T Simuni, O Bandmann… - The Lancet …, 2021 - thelancet.com
… animal models of Parkinson's disease have focused on recapitulating the loss of dopaminergic
neurons … of an agent in laboratory and animal models of mitochondrial dysfunction should …
neurons … of an agent in laboratory and animal models of mitochondrial dysfunction should …
[PDF][PDF] Nrf2/Wnt resilience orchestrates rejuvenation of glia-neuron dialogue in Parkinson's
B Marchettia - iris.unict.it
… to Parkinson's disease (PD), a common movement disorder … Using either in vivo murine
models overexpressing human α-… Astrocytes and microglia can protect neurons by scavenging …
models overexpressing human α-… Astrocytes and microglia can protect neurons by scavenging …
Microglial activation mediates noradrenergic locus coeruleus neurodegeneration via complement receptor 3 in a rotenone-induced Parkinson's disease mouse model
L Jing, L Hou, D Zhang, S Li, Z Ruan… - Journal of …, 2021 - Taylor & Francis
… activation and thus protected dopaminergic neurons in a PD rat model generated by … taurine
also attenuated dopaminergic neuronal loss in the PD mouse model generated by paraquat …
also attenuated dopaminergic neuronal loss in the PD mouse model generated by paraquat …
[HTML][HTML] HOTAIR drives autophagy in midbrain dopaminergic neurons in the substantia nigra compacta in a mouse model of Parkinson's disease by elevating NPTX2 …
Y Lang, Y Li, H Yu, L Lin, X Chen, S Wang… - Aging (albany …, 2020 - ncbi.nlm.nih.gov
… (miR-221-3p)/neuronal pentraxin II (NPTX2) axis in the process of dopaminergic neuron
autophagy using PD mouse models. The PD mouse models were established by intraperitoneal …
autophagy using PD mouse models. The PD mouse models were established by intraperitoneal …
Targeting Mitochondrial Complex I Deficiency in MPP+/MPTP-induced Parkinson's Disease Cell Culture and Mouse Models by Transducing Yeast NDI1 Gene
H Li, J Zhang, Y Shen, Y Ye, Q Jiang, L Chen… - Biological Procedures …, 2024 - Springer
… induced PD models by functionally compensating for the impaired complex I. MPP + -treated
SH-SY5Y cells and MPTP-treated mice were used as the PD cell culture and mouse models …
SH-SY5Y cells and MPTP-treated mice were used as the PD cell culture and mouse models …
… SVHRSP attenuates dopaminergic neurodegeneration by inhibiting NADPH oxidase-mediated neuroinflammation in experimental models of Parkinson's disease
X Zhang, D Tu, S Li, N Li, D Li, Y Gao, L Tian… - … Radical Biology and …, 2022 - Elsevier
… free radicals were detected in rodent models of PD, resulting in neuronal oxidative stress, …
mouse PD model, SVHRSP at 200 and 400 μg/kg protected dopaminergic neurons against …
mouse PD model, SVHRSP at 200 and 400 μg/kg protected dopaminergic neurons against …
[HTML][HTML] SRT1720 as an SIRT1 activator for alleviating paraquat-induced models of Parkinson's disease
CC Chao, CL Huang, JJ Cheng, CT Chiou, IJ Lee… - Redox Biology, 2022 - Elsevier
… animal models of PD. Here we show that SRT1720 alleviates PQ-induced toxicity in cell and
animal models… To validate the protection of SRT1720 against PQ-induced cytotoxicity within …
animal models… To validate the protection of SRT1720 against PQ-induced cytotoxicity within …