[HTML][HTML] Primary cilia and SHH signaling impairments in human and mouse models of Parkinson's disease
S Schmidt, MD Luecken, D Trümbach… - Nature …, 2022 - nature.com
… Accordingly, in these hiPSC-derived hNPCs and neurons, we observe a shortening of PC. …
human cellular and mouse models of familial PD. Furthermore, in sPD models, the shortening …
human cellular and mouse models of familial PD. Furthermore, in sPD models, the shortening …
[HTML][HTML] Combined cell-based therapy strategies for the treatment of Parkinson's disease: focus on mesenchymal stromal cells
J Rodríguez-Pallares, M García-Garrote… - Neural Regeneration …, 2023 - journals.lww.com
… transplantation developed in patients and animal models of Parkinson’s disease, with a focus
on … neurons would serve as a strategy to increase cell survival and improve graft outcomes. …
on … neurons would serve as a strategy to increase cell survival and improve graft outcomes. …
Role of dopamine neuron activity in Parkinson's disease pathophysiology
K Rademacher, K Nakamura - Experimental Neurology, 2024 - Elsevier
… of dopamine neurons is altered in Parkinson's disease (PD), … human data and studies in
animal models of PD. We then … to target and protect dopamine neurons from degeneration. …
animal models of PD. We then … to target and protect dopamine neurons from degeneration. …
Calcium Channel blockers are associated with reduced risk of Parkinson's disease in patients with hypertension: A population-based retrospective cohort study
YF Tseng, HC Lin, JCJ Chao, CY Hsu, HL Lin - Journal of the neurological …, 2021 - Elsevier
… SNcDA neurons to switch back to sodium channel use, thus reducing intraneuronal Ca 2+
concentration and energy demand (‘rejuvenation’) [7,13]; this might protect SNcDA neurons …
concentration and energy demand (‘rejuvenation’) [7,13]; this might protect SNcDA neurons …
[PDF][PDF] Abscisic acid ameliorates motor disabilities in 6-OHDA-induced mice model of Parkinson's disease
… Parkinson's disease (PD) is characterized by a myriad of … ABA on cognitive and motor
disorders, a mouse model of PD was … plays a crucial role in protecting mice from motor disabilities …
disorders, a mouse model of PD was … plays a crucial role in protecting mice from motor disabilities …
[HTML][HTML] CDNF and MANF in the brain dopamine system and their potential as treatment for Parkinson's disease
E Pakarinen, P Lindholm - Frontiers in psychiatry, 2023 - frontiersin.org
… animal models, and effects of CDNF and MANF in preclinical … unable to protect neurons
perfectly bound GRP78 (119). … Recently, MANF was associated with rejuvenating effects in …
perfectly bound GRP78 (119). … Recently, MANF was associated with rejuvenating effects in …
[HTML][HTML] Anti-apoptotic and anti-inflammatory role of trans ε-viniferin in a neuron–glia co-culture cellular model of Parkinson's disease
… as a mixture of viniferin and resveratrol protects neuronal dopaminergic cells from 6-OHDA-…
dopaminergic neuron death recapitulating the pathogenetic features of PD in rodent models …
dopaminergic neuron death recapitulating the pathogenetic features of PD in rodent models …
Neuroprotective effect of swertiamarin in a rotenone model of Parkinson's disease: role of neuroinflammation and alpha-synuclein accumulation
M Sharma, FM Malim, A Goswami… - ACS Pharmacology & …, 2022 - ACS Publications
… -treatment of SWE in the rotenone mice model induced a significant increase in TH
immunoreactivity in the striatum (p < 0.05) and an increase in the number of TH + neurons in SN (p < …
immunoreactivity in the striatum (p < 0.05) and an increase in the number of TH + neurons in SN (p < …
Pentraxin 3 secreted by human adipose‐derived stem cells promotes dopaminergic neuron repair in Parkinson's disease via the inhibition of apoptosis
… protected the dopaminergic neurons in the in vivo and vitro … the origin of the rejuvenated
dopaminergic fibers around the … PD mice model, based on the results of the present and previ…
dopaminergic fibers around the … PD mice model, based on the results of the present and previ…
[HTML][HTML] MicroRNA-124-3p-enriched small extracellular vesicles as a therapeutic approach for Parkinson's disease
M Esteves, R Abreu, H Fernandes, C Serra-Almeida… - Molecular Therapy, 2022 - cell.com
… effects in a mouse model of Parkinson’s disease. In vitro, miR-124-3p-loaded small extracellular
vesicles induced neuronal … We found that miR-124-3p sEVs protect DA neurons from 6-…
vesicles induced neuronal … We found that miR-124-3p sEVs protect DA neurons from 6-…