… who have developed early-onset PCa (< 55 years) (Mottet et … Genome-wide association
studies have identified 100 … are a late event in the pathology of prostate cancer. Other tumour …

… international urology bodies and associations suggests that the … Histology of the prostate
gland The prostate gland is made … 30-40% of cases of early onset of disease are inherited in a …

… in association with a personal history of BC or prostate cancer… on chromosome 17 was linked
to early onset familial BC, she … Moreover, we could not recollect the histology and the stage …

… not selected for a positive family history of cancer or early-onset disease. Germline genetic
… ability to uncover novel gene-disease associations in already existing genomic data sets. …

… The definitive diagnosis is histopathological in prostate biopsy … developed early‑onset PCa
(<55 years) (5). Although the … : A positive family history as a risk factor for prostate cancer in a …

… of metastatic disease, we examined the association of clinical … Consistent with known
association with aggressive disease … rely heavily on surgical pathology, including tumor stage and …

… Association of Medical Oncology, AIOM, NCCN). At this time, … an early onset BC and a
subsequent endometrial cancer; … , pancreas and prostate cancers) within the affected families, a …

… This thesis examined the association of PRS with biopsy … suggesting aggressive histology
and poor clinical outcomes) … degree relative (FDR) had early onset disease (≤55 years) with a …

… ’s family history is significant for early-onset colon cancer in … cancer, whereas his brother
had prostate cancer at 74 years. … Many biological and histopathological similarities and …

… Patients with early-onset lysosomal storage diseases are ideal candidates for prenatal …
The family history was positive for infantile-onset Pompe’s disease with cardiomyopathy in two …