[HTML][HTML] Biased, Bitopic, Opioid–Adrenergic Tethered Compounds May Improve Specificity, Lower Dosage and Enhance Agonist or Antagonist Function with Reduced …

R Root-Bernstein - Pharmaceuticals, 2022 - mdpi.com
… that adrenergic-opioid enhancement can be mediated by … is involved, the synergy that
results is mediated by these … human α2C-adrenergic receptor ligand that increased receptor

[HTML][HTML] In vitro and in silico characterization of G-protein coupled receptor (GPCR) targets of phlorofucofuroeckol-A and dieckol

P Paudel, SH Seong, SE Park, JH Ryu, HA Jung… - Marine Drugs, 2021 - mdpi.com
α2C adrenergic receptor (α 2C AR) and an antagonist effect at the adenosine 2A receptor (A
2A R), δ-opioid receptor (… At present, GPCRs mediate the effect of approximately one-third of …

[HTML][HTML] Zerumbone-induced analgesia modulated via potassium channels and opioid receptors in chronic constriction injury-induced neuropathic pain

B Gopalsamy, JSM Chia, AAO Farouk, MR Sulaiman… - Molecules, 2020 - mdpi.com
… maintenance of pain symptoms. Even though this chronic pain state is mediated by both …
The changes can occur in the peripheral nerves, dorsal root ganglion, spinal cord, along the …

… of clonidine and magnesium sulfate premedication on perioperative hormonal stress responses, hemodynamic stability and postoperative analgesia in patients with …

HS Mohamed Ali, GS Gad… - … Journal of Anaesthesia, 2022 - Taylor & Francis
… have better postoperative pain relief with lower consumption of rescue analgesics than in …
of post-operative pain represents a unique challenge and multimodal analgesia is usually …

management of pain associated with laminitis in the horse-evidence for therapies.

KL Ellis, MR King, KR Mama - 2020 - cabidigitallibrary.org
α2C-Adrenergic receptors mediate spinal analgesia and adrenergic-opioid synergy. J …
evoked by α2 agonists and is necessary for spinal adrenergic-opioid synergy. J Neurosci …

[PDF][PDF] Concomitant use of medetomidine and vatinoxan in laboratory and client-owned dogs–Effects on drug absorption and disposition

I Kallio-Kujala - 2021 - helda.helsinki.fi
… and any remaining spinal fluid or blood was absorbed with a gauze from the tissue samples.
Tissue samples were obtained from the lumbar and cervical spinal intumescences and from …