GPCRs in pancreatic adenocarcinoma: Contributors to tumour biology and novel therapeutic targets

K Sriram, C Salmerón, SZ Wiley… - British Journal of …, 2020 - Wiley Online Library
… protein 1 (AP-1) signalling, effects that were blocked by β 2 -adrenoceptor antagonists. …
that β 2 -adrenoceptor antagonists induce G 1/S cell cycle phase arrest and apoptotic cell …

Effect of chronic stress on tumorigenesis and development

C Wang, Y Shen, J Ni, W Hu, Y Yang - Cellular and Molecular Life …, 2022 - Springer
tumor development in mice of skin cancer model induced by … The activation of ARs in
pancreatic cancer cells activates the … VEGF, which could be effectively blocked via β-AR or MMP …

The use of antihypertensive drugs as coadjuvant therapy in cancer

JA Carlos-Escalante, M de Jesus-Sanchez… - Frontiers in …, 2021 - frontiersin.org
… the progression of pancreatic cancer precursor lesions by … proliferation and to induce G 0
/G 1 arrest in two cholangiocarcinoma … of β-blockade in prostate cancer have been published. …

Stress reduction strategies in breast cancer: Review of pharmacologic and non-pharmacologic based strategies

R Gosain, E Gage-Bouchard, C Ambrosone… - Seminars in …, 2020 - Springer
cancers have documented that β-blockers can arrest the stress-… stress-induced β-AR signaling
pathway in breast cancer patients and … Preclinical studies using pharmacologic blockade

Protease-activated receptors in health and disease

CJ Peach, LE Edgington-Mitchell… - Physiological …, 2023 - journals.physiology.org
… cells (21) and expression of PAR 1 in pancreatic tumor cells (… α 9 β 1 -integrin, leading to
enhanced migration blocked by a … peptides induce the assembly of PAR 2 , G protein, and β-…

Over a century since ephedrine discovery: an updated revisit to its pharmacological aspects, functionality and toxicity in comparison to its herbal extracts

MZ Gad, SS Azab, AR Khattab, MA Farag - Food & Function, 2021 - pubs.rsc.org
… ephedrine affinity to β-receptors is β 1 > β 2 > β 3 , which … sheep model of drug-induced
hypertension. Jain et al. pointed … of [ 3 H]-dopamine and blocked its uptake, which is suggestive …

Molecular Biology of Escherichia colt Shiga Toxins' Effects on Mammalian Cells.

C Menge - Toxins, 2020 - go.gale.com
arrests HCT116 cells in the S phase within 24 h, presumably by activation of the S phase
checkpoint prior to inducing apoptosis … signaling blocked the ability of Stxl to induce DUSP1 …

Wwox deficiency leads to neurodevelopmental and degenerative neuropathies and glycogen synthase kinase 3β-mediated epileptic seizure activity in mice

YY Cheng, YT Chou, FJ Lai, MS Jan, TH Chang… - Acta Neuropathologica …, 2020 - Springer
… The presentation rate of stimulation was 1/s. The … Racine scale: stage 0, no response;
stage 1, behavioral arrest followed by … Lithium treatment has also been shown to induce β-catenin-…

Bioinformatic scripts of the study: Haugg E, Borner J, Stalder G, Kübber-Heiss A, Giroud S, Herwig A (submitted September 2023) Comparative transcriptomics of the …

A Herwig, J Borner, E Haugg - 2023 - oparu.uni-ulm.de
… adenosine A3 receptor O adenosine receptor A3|G-protein coupled receptor 2 20230309 -
… protein-coding Ank3 ankyrin 3, epithelial O ankyrin-3|brain-specific ankyrin-G 20230221 - …