[HTML][HTML] Radiation-induced cell death and its mechanisms

Y Jiao, F Cao, H Liu - Health physics, 2022 - journals.lww.com
… of cancer cells after irradiation. Many glycolysis regulatory genes and specific markers of
mitophagy are upregulated in irradiated cells, thus providing a survival advantage for cells. This …

Immunological impact of cell death signaling driven by radiation on the tumor microenvironment

ME Rodriguez-Ruiz, I Vitale, KJ Harrington… - Nature …, 2020 - nature.com
… support antigen-independent NK cell activation against irradiated cells, especially when the
… lipid peroxidation in cancer cells that can be further exacerbated by IFN-γ 126 . Moreover, …

[HTML][HTML] Immunogenic cell death induction by ionizing radiation

M Zhu, M Yang, J Zhang, Y Yin, X Fan… - Frontiers in …, 2021 - frontiersin.org
… with irradiation, the clinical evidence of ICD, and immunogenic forms of cell death. Finally, …
There, DCs produce IL-6, IL-1β, TNF-α, and IFN-γ and cross-present antigens to boost T-cell

[HTML][HTML] Targeting purinergic pathway to enhance radiotherapy-induced immunogenic cancer cell death

X Bao, L Xie - Journal of Experimental & Clinical Cancer Research, 2022 - Springer
… and CD73 promoted γ-irradiation-induced cell death while suppressed γ-irradiation-induced
cell migration and actin remodeling [83]. In human pancreatic cancer cell line MIA PaCa-2, …

[HTML][HTML] Molecular mechanisms of radiation-induced cancer cell death: a primer

J Sia, R Szmyd, E Hau, HE Gee - … in cell and developmental biology, 2020 - frontiersin.org
… The type of cell death after irradiation depends on a number of … cell death after irradiation,
with a reduction in chromosomal aberrations and reproductive capacity of cells irradiated

[HTML][HTML] Ionizing radiation results in a mixture of cellular outcomes including mitotic catastrophe, senescence, methuosis, and iron-dependent cell death

S Adjemian, T Oltean, S Martens, B Wiernicki… - Cell death & …, 2020 - nature.com
… our experimental setup irradiated cells could undergo a necroptotic cell death modality, we
… did not rescue irradiated cells, in line with our results that other cellular stress and cell death

[HTML][HTML] Mild mitochondrial uncoupling protects from ionizing radiation induced cell death by attenuating oxidative stress and mitochondrial damage

Y Rai, N Kumari, S Singh, N Kalra, R Soni… - … et Biophysica Acta (BBA …, 2021 - Elsevier
Cells were irradiated with 4Gy γ-irradiation, and cell numbers of mentioned treatment
groups enumerated at 24, 48, and 72 h post-IR. The graph plotted as Nt/N0 at 24, 48, and 72 h …

[HTML][HTML] Immunogenic cell death, DAMPs and prothymosin α as a putative anticancer immune response biomarker

AI Birmpilis, A Paschalis, A Mourkakis, P Christodoulou… - Cells, 2022 - mdpi.com
… Moreover, depending on the mode of cell death induced, we … in the microenvironment of
the dying cells, whereas, during … H929 cells were also driven to apoptosis after γ-irradiation (2…

[HTML][HTML] Combination of cisplatin and irradiation induces immunogenic cell death and potentiates postirradiation anti–PD-1 treatment efficacy in urothelial carcinoma

H Fukushima, S Yoshida, T Kijima, Y Nakamura… - International Journal of …, 2021 - mdpi.com
… IFN-γ + CD8 + CD4 − T cell expression did not differ between … cisplatin and irradiation induced
immunogenic cell death to a … combination of cisplatin and irradiation. Moreover, because …

Dark side of cytotoxic therapy: chemoradiation-induced cell death and tumor repopulation

M Jiang, D Gu, J Dai, Q Huang, L Tian - Trends in cancer, 2020 - cell.com
… In recent years, dying cells … of cell death and release complex factors and thus orchestrate
tumor repopulation cascades. Dying cells potentiate the survival of residual living tumor cells, …