Seeing (and using) the light: recent developments in bioluminescence technology

AC Love, JA Prescher - Cell Chemical Biology, 2020 - cell.com
Luciferaseluciferin reactions can drive light-activatable proteins, ultimately triggering … We
showcase how new luciferins and engineered luciferases are expanding the scope of optical …

Applications of bioluminescence in biotechnology and beyond

AJ Syed, JC Anderson - Chemical Society Reviews, 2021 - pubs.rsc.org
applications fuelled by great advances in protein engineering, synthetic chemistry, physics
and light … used natural luciferin/luciferase pairs, with a brief mention of their uses as well as …

Recent achievements of bioluminescence imaging based on firefly luciferin-luciferase system

S Li, Z Ruan, H Zhang, H Xu - European Journal of Medicinal Chemistry, 2021 - Elsevier
light on the diagnosis and treatment of various diseases. … therapeutic application of BLI based
on firefly luciferin-luciferase … and the mutant luciferase-luciferin pairs over the past decade. …

A Comprehensive Exploration of Bioluminescence Systems, Mechanisms, and Advanced Assays for Versatile Applications

AN Dunuweera, SP Dunuweera… - Biochemistry …, 2024 - Wiley Online Library
… of light emission from living creatures. It happens when the enzyme luciferase facilitates the
oxidation of luciferin, … Although marine luciferases catalyze light emission, these chemical

Luciferin bioluminescence

FM McCapra, KD Perring - Chemi-and Bioluminescence, 2020 - api.taylorfrancis.com
luciferin for the oxidizable organic substrate and luciferase for the enzyme which catalyzes
the oxidative light-… chapter is on the chemical features of bioluminescence involving discrete …

Coelenterazine-dependent luciferases as a powerful analytical tool for research and biomedical applications

VV Krasitskaya, EE Bashmakova, LA Frank - International Journal of …, 2020 - mdpi.com
… In case (b), luciferase and preoxydized luciferin are stable … So, light energy produced
by CTZ-dependent luciferases is … bioluminescent activity upon chemical conjugation with …

Bioluminescence imaging in mice with synthetic luciferin analogues

X Ji, ST Adams Jr, SC Miller - Methods in enzymology, 2020 - Elsevier
… Here we describe how synthetic analogues of the firefly luciferase substrate d-luciferin differ
in their in vivo … Light emission only occurs where the luciferase expression overlaps with …

Luciferins under construction: a review of known biosynthetic pathways

AS Tsarkova - Frontiers in Ecology and Evolution, 2021 - frontiersin.org
Chemical structures of ten biochemically unrelated luciferins … Various luciferins, the small
molecules capable of light … follow classical pathway of luciferase-catalyzed luciferin oxidation, …

[PDF][PDF] Chapter-8 Bioluminesence:“The Living Light

A Ghabru, N Rana, G Verma - Molecular Biology Plant Physiology, 2023 - researchgate.net
luciferin-luciferase pairs have different light emission wavelengths and hence are suitable
for various applications. … , synthetic chemistry and physics which have allowed luciferins and …

How to select firefly luciferin analogues for in vivo imaging

R Saito-Moriya, J Nakayama, G Kamiya… - International Journal of …, 2021 - mdpi.com
… Such reactions produce light upon the oxidation of a luciferinluciferin analogues and/or
luciferase mutants, for application in … the chemical and physical properties of luciferin analogues …