[HTML][HTML] Evaluation of the early-phase [18F] AV45 PET as an optimal surrogate of [18F] FDG PET in ageing and Alzheimer's clinical syndrome

M Vanhoutte, B Landeau, S Sherif, V de la Sayette… - NeuroImage: Clinical, 2021 - Elsevier
… eAV45 as an optimal proxy of [ 18 F]FDG PET in a large mixed… (PET), measuring the reduction
of cerebral metabolic rate of … Previous studies showed that the relative delivery rate R 1 , …

[HTML][HTML] Dual-phase 18F-florbetaben PET provides cerebral perfusion proxy along with beta-amyloid burden in Alzheimer's disease

HJ Yoon, BS Kim, JH Jeong, GH Kim, HK Park… - NeuroImage: Clinical, 2021 - Elsevier
… A dynamic PET scan was obtained in the early phase (0–10 … , the ratio of K1 to its reference
region value (delivery rate, R1), … Such a dual-phase PET protocol would reduce patient cost

Simulating the effect of cerebral blood flow changes on regional quantification of [18F]flutemetamol and [18F]florbetaben studies

F Heeman, M Yaqub, I Lopes Alves… - Journal of Cerebral …, 2021 - journals.sagepub.com
… are acquired separately for early and late phases of tracer uptake to reduce overall scanning
… Given that the rate constant for tracer delivery (K 1 ) can be considered a proxy for blood …

High Correlation of Static First-Minute-Frame (FMF) PET Imaging after 18F-Labeled Amyloid Tracer Injection with [18F]FDG PET Imaging

AP Seiffert, A Gómez-Grande, A Villarejo-Galende… - Sensors, 2021 - mdpi.com
… dynamic imaging of early phase amyloid PET and be used … of static brain amyloid PET images
obtained in the first minute … Using the Benjamini–Hochberg procedure, false discovery rate

A kinetics-based approach to amyloid PET semi-quantification

A Chincarini, E Peira, M Corosu, S Morbelli… - European journal of …, 2020 - Springer
… so that E can be taken as a proxy of brain perfusion [20,21,22,… on the L scan intensity
distribution. This value was chosen so … to the brain as a function of rCBF, with a ratio of about 0.8 …

Longitudinal evaluation of surrogates of regional cerebral blood flow computed from dynamic amyloid PET imaging

M Bilgel, L Beason-Held, Y An, Y Zhou… - Journal of Cerebral …, 2020 - journals.sagepub.com
… unitless relative delivery parameter R 1 given by the ratio of … Therefore, characterization
of neuronal activity, a proxy for … of early-phase 18F-florbetapir (AV-45/Amyvid) PET images …

Precision estimates of relative and absolute cerebral blood flow in Alzheimer's disease and cognitively normal individuals

F Heeman, D Visser, M Yaqub… - Journal of Cerebral …, 2023 - journals.sagepub.com
… whether a proxy of CBF can be derived from the early distribution phase of PET tracers that
… frame standardized uptake value ratio) have led to an increased interest in so called dual-…

Tau pathology and relative cerebral blood flow are independently associated with cognition in Alzheimer's disease

D Visser, EE Wolters, SCJ Verfaillie… - European journal of …, 2020 - Springer
… of tracer delivery, which can be interpreted as a proxy of relative … R 1 represents the ratio
between the rate constant for ligand … The present study used R 1 as proxy for rCBF, and in line …

Longitudinal tau PET using [18F]flortaucipir: Comparison of (semi)quantitative parameters

D Visser, H Tuncel, R Ossenkoppele, M Yaqub… - medRxiv, 2021 - medrxiv.org
… With dynamic scanning protocols, on the other hand, the PET … a dynamic PET scan, such as
distribution volume ratio (DVR) … tracer delivery (R 1 ), a proxy for relative cerebral blood flow (…

Test-Retest Variability of Relative Tracer Delivery Rate as Measured by [11C]PiB

F Heeman, J Hendriks, I Lopes Alves… - Molecular Imaging and …, 2021 - Springer
proxy of cerebral perfusion can be obtained from the early frames of dynamic scans using
currently available PET … The relative influx rate (R 1 =K 1 /K 1 ’), which can be calculated from …