Using 3D in vitro cell culture models in anti-cancer drug discovery

SA Langhans - Expert Opinion on Drug Discovery, 2021 - Taylor & Francis
3D cell culture system is chosen for drug discovery and should be based on factors like
drug target and tumor … relevance of a 3D cell culture system can only be as good as our …

[HTML][HTML] 3D cell culture models as recapitulators of the tumor microenvironment for the screening of anti-cancer drugs

MAG Barbosa, CPR Xavier, RF Pereira, V Petrikaitė… - Cancers, 2021 - mdpi.com
… summarize the 3D tumor models available for drug screening, … ’s tumor to a drug, being
highly promising for personalized … direct co-culture of several cell types, namely tumor cells and …

[HTML][HTML] Three-dimensional in vitro cell culture models for efficient drug discovery: Progress so far and future prospects

SM Badr-Eldin, HM Aldawsari, S Kotta, PK Deb… - Pharmaceuticals, 2022 - mdpi.com
… of 3D cell culture approaches and emphasizes different 3D … Two traditional and promising
approaches in drug discovery … used for levitation for co-culture of tumor cells along with …

Microengineered 3D tumor models for anti-cancer drug discovery in female-related cancers

F Amirghasemi, E Adjei-Sowah, BA Pockaj… - Annals of Biomedical …, 2021 - Springer
development of microengineered tumor models for anti-cancer drug discovery and screening
… Although relatively new, these advances hold promising results for patients and present an …

[HTML][HTML] Three-dimensional cell cultures as an in vitro tool for prostate cancer modeling and drug discovery

F Fontana, M Raimondi, M Marzagalli… - International journal of …, 2020 - mdpi.com
… their crucial role in tumor modeling and drug discovery. … alternative, promising approach
consisting of the ex vivo 3D culture … , a co-culture 3D model of PCa cells and cancer-associated …

Generation and analysis of 3D cell culture models for drug discovery

L Belfiore, B Aghaei, AMK Law, JC Dobrowolski… - … of Pharmaceutical …, 2021 - Elsevier
… , 3D cell culture enables co-culture of cancer cells and … is promising for a wide range of
research and drug screening3D cell model for studying the interactions between tumour and …

[HTML][HTML] 3D cancer models: One step closer to in vitro human studies

N Manduca, E Maccafeo, R De Maria, A Sistigu… - Frontiers in …, 2023 - frontiersin.org
… and Tumor-on-a-Chip (ToC) models, for the development of … only cancer cells and do not
support long-term co-culture of … implementation in disease modeling and drug discovery. Our …

[HTML][HTML] Modeling the tumor immune microenvironment for drug discovery using 3D culture

JY Lee, O Chaudhuri - APL bioengineering, 2021 - pubs.aip.org
Drugs nominated as clinical candidates are only as good as the assay cascades used to …
TME to recruit immune cells, a 3D co-culture containing only cancer spheroids and CAFs could …

[HTML][HTML] Patient-derived in vitro models for drug discovery in colorectal carcinoma

GM Ramzy, T Koessler, E Ducrey, T McKee, F Ris… - Cancers, 2020 - mdpi.com
… short-term 3D spheroid model, where human CRC cells were … of spheroid co-culture models
to human tumor types will make … be a promising approach to better understanding the tumor

[HTML][HTML] The revolutionary roads to study cellcell interactions in 3d in vitro pancreatic cancer models

D Delle Cave, R Rizzo, B Sainz Jr, G Gigli… - Cancers, 2021 - mdpi.com
… platforms for anticancer drug discovery in pancreatic cancer, … set up a 3D co-culture system
of CAFs and tumor cells. The … In this regard, one of the most promising approaches consists in …