[HTML][HTML] In vitro 3D cultures to model the tumor microenvironment

F Fontana, M Marzagalli, M Sommariva, N Gagliano… - Cancers, 2021 - mdpi.com
… advances in cancer modeling and drug discovery and testing. … shown promise not only in
cancer modeling but also in drug … , 3D co-culture models with tumor and stromal cells have …

[HTML][HTML] 3D cancer models: One step closer to in vitro human studies

N Manduca, E Maccafeo, R De Maria, A Sistigu… - Frontiers in …, 2023 - frontiersin.org
… and Tumor-on-a-Chip (ToC) models, for the development of … only cancer cells and do not
support long-term co-culture of … implementation in disease modeling and drug discovery. Our …

[HTML][HTML] Patient-derived organoids as a model for cancer drug discovery

C Rae, F Amato, C Braconi - International journal of molecular sciences, 2021 - mdpi.com
… , the use of co-culture systems will allow the role of the tumour … include 3D bioprinting and
microfluidic systems, co-culture … A protocol for the drug screening of organoids derived from …

Advances in the use of 3D colorectal cancer models for novel drug discovery

A Baiao, S Dias, AF Soares, CL Pereira… - … on drug discovery, 2022 - Taylor & Francis
… The first example of tumors development in 3D is the production of spheroids and is being
… the most promising approach in what concerns the production of tumor mimetic models […

[HTML][HTML] Newly developed 3D in vitro models to study tumor–immune interaction

P Mu, S Zhou, T Lv, F Xia, L Shen, J Wan… - … Cancer Research, 2023 - Springer
tumors and has long been a promising direction in oncology … 2D tumor co-culture models
and humanized mouse modelstumor microenvironment and can be used for drug screening

[HTML][HTML] Clinical application perspectives of lung cancers 3D tumor microenvironment models for in vitro cultures

I Wieleba, K Wojas-Krawczyk, P Krawczyk… - International Journal of …, 2022 - mdpi.com
… Thorough analysis of pre-clinical models of NSCLC were … lung cancer research, taking into
account the key features of tumor–… ’ co-culture use is required to induce tumor plasticity in 3D

Addressing the tumour microenvironment in early drug discovery: a strategy to overcome drug resistance and identify novel targets for cancer therapy

E Kaemmerer, D Loessner, VM Avery - Drug Discovery Today, 2021 - Elsevier
… compatibility of advanced 3D cancer models with automation … Co-culture of MSCs and
breast cancer cells pretreated with … β1 also showed promising results in a 3D cell culture assay, …

[HTML][HTML] Three-dimensional (3D) cell culture: a valuable step in advancing treatments for human hepatocellular carcinoma

AF Khafaga, SA Mousa, L Aleya… - Cancer Cell …, 2022 - Springer
… (3D) tissue models in vitro is critical for drug discovery … drop method and via co-culture
of stromal fibroblasts with liver … The use of 3D spheroid culture of HCC cells is promising for …

[HTML][HTML] Advances in the application of 3D tumor models in precision oncology and drug screening

X Guan, S Huang - Frontiers in Bioengineering and Biotechnology, 2022 - frontiersin.org
drug development and in guiding individualized therapies. 3D tumor models also provide
a promising … Multiple cell co-culture models based on scaffolds have been widely studied. …

[HTML][HTML] The variety of 3D breast cancer models for the study of tumor physiology and drug screening

E Fröhlich - International Journal of Molecular Sciences, 2023 - mdpi.com
… Animal models are still the gold standard in studies on tumor … the validation of promising
compounds for cancer treatment. … cells were more similar to aggressive tumors in co-culture with …