Transcription by RNA polymerase II and the CTD-chromatin crosstalk

N Singh, M Asalam, MO Ansari, NS Gerasimova… - Biochemical and …, 2022 - Elsevier
essential for the regulation of mRNA transcription [14,15]. … motif at its c-terminus which mimics
the phosphorylated CTD to … transcription, the histone tails, acetylated at lysine residues by …

Removing quote marks from the RNA polymerase II CTD 'code'

G Dieci - Biosystems, 2021 - Elsevier
… the RNA polymerase II carboxy-terminal domain (Pol II CTD). … of specific motifs on the nascent
RNA and through interaction … Pol II CTD-dependent coordination of transcription with RNA

The CTD is not essential for the post-initiation control of RNA polymerase II activity

A Gerber, RG Roeder - Journal of molecular biology, 2020 - Elsevier
… The RNA polymerase II (Pol II) C-terminal domain (CTD), is a … The CTD in mammals is
composed of 52 heptad motifs (with … (c) Schematic representation of the Pol II transcription cycle …

Transcription activation depends on the length of the RNA polymerase II Cterminal domain

…, M Lidschreiber, X Darzacq, C Dugast‐Darzacq… - The EMBO …, 2021 - embopress.org
… We suggest that a long CTD is required for efficient enhancer‐dependent recruitment of …
Here, we investigate how shortening of the Pol II CTD influences transcription kinetics in human …

A combinatorial view of old and new RNA polymerase II modifications

DE Lyons, S McMahon, M Ott - Transcription, 2020 - Taylor & Francis
… of the C-terminal domain (CTD) of RNA polymerase II. The … , but modifications of all residues
have been described. Here… to recognize phosphorylated serine-proline motifs (Ser2-Pro3 or …

What is the switch for coupling transcription and splicing? RNA polymerase II Cterminal domain phosphorylation, phase separation and beyond

H Maita, S Nakagawa - Wiley Interdisciplinary Reviews: RNA, 2020 - Wiley Online Library
RNA polymerase II C-terminal domain (Pol II CTD) has important roles in the kinetic coupling
of splicing with transcription, which is essential for … abundantly phosphorylated residues, but …

Structural motifs for CTD kinase specificity on RNA polymerase II during eukaryotic transcription

MKV Ramani, EE Escobar, S Irani… - ACS chemical …, 2020 - ACS Publications
residues of the repetitive heptad of the C-terminal domain (CTD) of the biggest subunit of RNA
polymerase II … since nonphosphorylated CTD is required for RNA polymerase II to recycle …

Structure of TFIIK for phosphorylation of CTD of RNA polymerase II

T van Eeuwen, T Li, HJ Kim, JJ Gorbea Colón… - Science …, 2021 - science.org
… ) containing pol II and all five general transcription factors (8, … The X-DFG motif at the N
terminus of the activation loop was … The peptide was modified on the N and C terminus by adding …

Termination of non‐coding transcription in yeast relies on both an RNA Pol II CTD interaction domain and a CTD‐mimicking region in Sen1

Z Han, O Jasnovidova, N Haidara, A Tudek… - The EMBO …, 2020 - embopress.org
… Here, we identify a motif in an intrinsically disordered region … ; (ii) they contain a Y residue
followed by several aa at the C‐… to an HTP‐tag at the C terminus (Appendix Table S5). We …

[HTML][HTML] Structure and mechanism of the RNA polymerase II transcription machinery

AC Schier, DJ Taatjes - Genes & development, 2020 - genesdev.cshlp.org
… upon the role of promoter sequence motifs, and we define a … the TBP C terminus, whereas
Spt8 occupies an N-terminal TBP … As a long, highly disordered sequence, the Pol II CTD also …