Spinal cannabinoid receptor 2 activation reduces hypersensitivity associated with bone cancer pain and improves the integrity of the blood–spinal cord barrier

C Wang, K Xu, Y Wang, Y Mao, Y Huang… - … Anesthesia & Pain …, 2020 - rapm.bmj.com
… ,23 remifentanil-induced hyperalgesia5 and cancer-induced pain.18 In the present study, …
or intraperitoneal injection of CB2 receptor agonist attenuates bone cancer pain and induces a …

The endocannabinoid system alleviates pain in a murine model of cancer-induced bone pain

AL Thompson, SA Grenald, HA Ciccone… - … of Pharmacology and …, 2020 - ASPET
cannabinoid system that is effective at reducing pain in a mouse model of metastatic breast
cancer to bone… CB2 antagonists attenuate MJN110 effects against cancer-induced flinching …

Role of classical cannabinoid receptors in cancer-associated bone disease

AI Idris - Bone Sarcomas and Bone Metastases-From Bench to …, 2022 - Elsevier
… on breast cancerinduced bone disease by testing the effects of MAGL manipulation on … of
the synthetic cannabinoid receptor agonists WIN-55,212-2 and AM1241 reduced bone pain in …

Classical cannabinoid receptors as target in cancer-induced bone pain: a systematic review, meta-analysis and bioinformatics validation

F Zeng, A Wade, K Harbert, S Patel, JS Holley… - Scientific Reports, 2024 - nature.com
cannabinoid type 1 (CB 1 ) and 2 (CB 2 ) receptors attenuate cancer-induced bone pain, we
… altogether indicate that CB 1/2 ligands attenuate cancer-induced bone pain in rodents, and …

Potential therapeutic treatments of cancer-induced bone pain

HM Ellingson, TW Vanderah - Current opinion in supportive and …, 2020 - journals.lww.com
… -ethyl} morpholine effectively attenuating CIBP in mice. Cannabinoid receptor agonists have
… have been shown to produce antinociception and attenuate morphine-induced dependence …

Activation of cannabinoid receptors in breast cancer cells improves osteoblast viability in cancer-bone interaction model while reducing breast cancer cell survival and …

T Khunluck, K Lertsuwan, C Chutoe, S Sooksawanwit… - Scientific reports, 2022 - nature.com
… Previous studies demonstrated that breast cancer induced osteoblast apoptosis and … can
cause osteolytic bone lesion resulting in bone loss and cancer-induced bone pain. Meanwhile, …

Cancer induced bone pain: current management and future perspectives

R Kapoor, AK Saxena, P Vasudev, D Sundriyal… - Medical Oncology, 2021 - Springer
… that cannabinoids can attenuate severe bone pain and also suppress cancer growth and
reduced bone loss … It has been proposed that concurrent use of cannabis receptor agonists and …

Components of the endocannabinoid system and effects of cannabinoids against bone diseases: a mini-review

Y Xin, A Tang, S Pan, J Zhang - Frontiers in Pharmacology, 2022 - frontiersin.org
… (OA), prevent osteoporosis (OP), reduce cancer-induced osteolytic destruction, and improve
… that alveolar bone loss was greatly attenuated by the use of CB-2 receptor agonist HU-308 …

Recent advances on type-2 cannabinoid (CB2) receptor agonists and their therapeutic potential

V Gasperi, T Guzzo, A Topai… - Current medicinal …, 2023 - ingentaconnect.com
… diseases, targeting CB2/TLR crosstal appears crucial to attenuate brain damage. … reduced
pain and suppressed neuropathic pain with sustained efficacy while attenuating morphine de…

Cannabidiol and cannabigerol, nonpsychotropic cannabinoids, as analgesics that effectively manage bone fracture pain and promote healing in mice

DK Khajuria, V Karuppagounder… - Journal of Bone and …, 2023 - academic.oup.com
bone in a rat fracture model, ( 22 ) and another study demonstrated that CBD attenuated bone
loss in a … reported that CNR2 agonists could reduce breast cancerinduced bone loss and …