… light on the origins of PDAC from the perspective of major oncogenic signaling pathways.
We … SHH pathway plays a major role in embryonic development such as body axis formation, …

… The prognosis of patients with pancreatic ductal adenocarcinoma (PDAC), the main …
pancreatic intraepithelial neoplasia lesions, revealing the central role of the RAF/MEK/ERK pathway …

… pivotal roles in development of PDAC from pancreatitis [12]. … A study of CP patients with a
smoking history has been … , aberrant Hh signaling contributes to the significant up-regulation of …

… which interplay with cancer types and tissue origins [38], adding … the activation loop, play key
roles. The NTA motif contains … in pancreatic ductal adenocarcinoma are at the position G12, …

… The tyrosine kinase receptor EGFR/ERBB1 plays an essential role in pancreatic … ability to
faithfully predict ERBB signaling in mice, we next applied it to human pancreas. The structure of …

… is passed on by a chain of kinase reactions, overall establishing MAPK signaling pathway […
of this pathway, which is crucial for pancreatic cancer (Fig. 2). Interestingly, MAPK kinases are …

… in KRAS mutant pancreatic ductal adenocarcinoma (PDAC). … data support the key role of
the RAF-MEK-ERK mitogen-… with the major role of the ERK MAPK effector pathway in driving …

… ERK MAPK signaling as an anti-KRAS therapy for PDAC. In particular, we also summarize
the key role … RAS-addicted cancer, pancreatic ductal adenocarcinoma, and on the importance …

… cancer have evidenced that acinar cells are the main cellular origin of PDAC. Acinar cells, …
play a central role in TME remodeling via the IL4-IL4R-Janus kinase (JAK)-signal transducer …

… as an oncogene in malignancies of pancreatic origin [13]. … suggests that pancreatic
desmoplastic protumor signaling is … does not play a significant role in the peptide phosphorylation …