… , suggesting an essential role of the innate … pancreatic cancer, and therefore there has
always been a great deal of interest in targeting the MAPK pathway in the treatment of pancreatic …

… Pancreatic ductal adenocarcinoma (PDAC) develops via … (MAPK) contributed by attenuation
of DUSP6 plays a key role in … , and history of chronic pancreatitis between the familial …

… cells based on their origin, for example, carcinoma (cancer of epithelial … signaling plays a
crucial role in pancreatic cell development, and addressing Notch as a remedy for pancreatic …

… (PDAC), the epigenetic changes play a significant role. … Majority of PanCa is exocrine in origin
that develops from ductal … -of-function of key processes and signaling properties. Detection …

… signalling components from normal pancreas tissue, through pre-invasive acinar to ductal
metaplasia and pancreatic … of both exogenous and endogenous origin [37]. Different …

… pathway is the Wnt-Ca 2+ -dependent signalling cascade [57]. In pancreatic ductal
adenocarcinoma, canonical Wnt signalling … secreted by pancreatic cancer cells, plays a major role …

… The SMAD4 gene, also known as DPC4 (deleted in pancreatic carcinoma 4), is inactivated
… a crucial role in signaling via the TGF-β pathway. The canonical TGF-β signaling pathway is …

… The role of SYPL1 in pancreatic ductal adenocarcinoma (PDAC) and … ERKs). We demonstrated
that SYPL1 promoted PDAC progression through its regulation of the ROS/ERK pathway. …

… They play crucial roles in the execution of diverse cellular functions (5, 6). Cancer cells have
distinct characteristics of abnormal cell proliferation, apoptosis inhibition, active migration, …

… Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancer … is crucial in
order to identify potential novel diagnostic and therapeutic targets. The most common signalling …