… , colorectal carcinoma, pancreatic ductal adenocarcinoma, … RAS-RAF-MEK-ERK pathway is
known to play a crucial role in … or pancreatic origin (179). Tumor cells in for instance lung and …

… regulated kinase signaling network (kinome) in KRAS-mutant pancreatic ductal adenocarcinoma
(… Consistent with a crucial role for the downregulated kinases in promoting KRAS-driven …

… signals are transmitted by homo- or heterodimerization with other ERBB receptors in order
to induce intracellular signaling via the RAS/RAF/MEK/MAPK … play a significant role in PDAC …

… adaptation of pancreatic ductal adenocarcinoma (PDA) cells … Our findings highlight a pivotal
role for transcriptional … reprogramming in response to MAPK pathway suppression in PDA. …

… More and more evidences have demonstrated the crucial roles of miRNAs in human
cancers [19,20,21]. MiR-429 is a cancer-related miRNA whose aberrant expression has been …

… Most pancreatic tumours arise in the exocrine tissue with pancreatic ductal adenocarcinoma
… Despite the described role of κB-Ras proteins in inflammatory signalling in macrophages 13 …

… cancer depending on the cell type of origin. PDACs, which … illness pancreatic ductal
adenocarcinoma (PDAC) has a significant … -mediated RAS signalling plays a crucial role in the …

… fulfill key roles in pancreatic tumorigenesis including the transition of pancreatic precursors
… The deregulation of the mTOR pathway is not of crucial importance in treatment of PDAC. …

… pancreatic ductal system. While the development and progression of precancerous lesions
have been well studied, the origins … , the RAS pathway plays a major role in PDAC initiation. …

… both a direct precursor to invasive lesion sequence related to the intestinal pathway and
alternative mechanisms with a separate onset of IPMN and PDAC from a common origin. …