… -workers established a chemical genetic method for targeting protein kinases, often referred
… of the protein kinase and a small-molecule inhibitor is accomplished by mutating an …

… alleles’ could be important tools for interrogating protein–protein interactions with precise
chemical … Furthermore, we believe that characterizing resistance mutations for protein–protein …

… protein structure and function. Herein, we identified allele-specific functional differences
among ex19del variants attributable to recurring sequence and structure motifs. We built all-…

… an array of protein kinases to aid in the discovery of chemical probes to further understand
each kinase’… contains 518 genes that encode for serine/threonine/tyrosine kinases, each with …

… chemical genetics in analog-sensitive protein kinase mutants and highlight selected strategies
for identifying protein kinase … powerful allele-specific chemical genetics strategies [58,59]. …

… to over 80 protein kinases, the implementation for kinases phosphorylating small molecules,
… cerevisiae VPS34, a PI3 kinase, yielded an active mutant allele, however, mutation of the …

… elegans zygotes, in which RNAi allows highly efficient depletion of the relevant players,
including the key polarity kinase atypical protein kinase C (PKC-3 in C. elegans ). Indeed, work …

… protein kinases, the kinase domain of EGFR is comprised of a smaller Nterminal lobe (N-lobe)
with a five-stranded β-sheet and an … than that of the inhibitor-sensitive L858R mutant, …

… Somatic mutations in kinase genes can affect drug treatment, both sensitivity and resistance…
publications, we applied it to all the protein kinases and collected drug response data. …

… to other kinases with an αD-1 cysteine such as for BTK, BLK, and JAK3 in vitro and in cellulo,
which paves the road for new design strategies for drugging kinase and nonkinase targets …