Interferon response in hepatitis C virus-infected hepatocytes: issues to consider in the era of direct-acting antivirals

PS Sung, EC Shin - International journal of molecular sciences, 2020 - mdpi.com
… Herein, we review recent studies on types I and III IFN responses in … related to IFN responses
in the direct-acting antiviral era. … that HCV infections induced IFN-λ4 expression at both the …

HCV cure with direct-acting antivirals improves liver and immunological markers in HIV/HCV-coinfected patients

Ó Brochado-Kith, I Martínez, J Berenguer… - Frontiers in …, 2021 - frontiersin.org
… production of inflammatory mediators and interferon-stimulated genes (… analyzed the gene
expression between groups by generalized linear models (GLM) for non-paired comparison

[HTML][HTML] Direct-acting antivirals for patients with chronic hepatitis C and hepatocellular carcinoma in Taiwan

CT Chi, CY Chen, CW Su, PY Chen, CJ Chu… - Journal of Microbiology …, 2021 - Elsevier
… from interferon (IFN)-based therapy to direct acting antivirals (DAAs). The effect of antiviral
… Continuous variables were expressed as mean with standard deviation and median with …

The impact of direct-acting antivirals on overall mortality and tumoral recurrence in patients with hepatocellular carcinoma listed for liver transplantation: an …

A Gorgen, Z Galvin, AC Huang, C Vinaixa… - …, 2020 - journals.lww.com
… Results of the multivariate analysis were expressed as HR with 95% CI. A P < 0.05 (2-… )
patients had been treated with IFN, and 642 (73.4%) patients were antiviral naïve at the time of LT …

Functional comparison of interferon‐α subtypes reveals potent hepatitis B virus suppression by a concerted action of interferon‐α and interferon‐γ signaling

J Chen, Y Li, F Lai, Y Wang, K Sutter, U Dittmer… - …, 2021 - Wiley Online Library
… , we observed a positive correlation of the inhibitory effect of specific IFN-α subtypes on HBV
RNA and HBeAg expression levels with their binding affinity to IFNAR1, but not to IFNAR2 (…

Directly acting antivirals for COVID-19: where do we stand?

SL Teoh, YH Lim, NM Lai, SWH Lee - Frontiers in microbiology, 2020 - frontiersin.org
… other products such as human immunoglobulin, interferons, carrimycin, bevacizumab, cobicistat,
… Disclaimer: All claims expressed in this article are solely those of the authors and do not …

IFN-λ1 displays various levels of antiviral activity in vitro in a select panel of RNA viruses

M Plotnikova, A Lozhkov, E Romanovskaya-Romanko… - Viruses, 2021 - mdpi.com
Antiviral Effect against Influenza To study the potential antiviral effects of type III interferon, …
We have shown an increase in SOCS-1 expression in response to both IVA infection and IFN-…

Hepatocellular carcinoma risk according to regimens for eradication of hepatitis C virus; interferon or direct acting antivirals

HW Lee, DH Han, HJ Shin, JS Lee, SU Kim, JY Park… - Cancers, 2020 - mdpi.com
… Simple Summary Owing to pegylated interferon (PegIFN)-free direct-acting antivirals (DAAs)
against chronic hepatitis C virus infection, a sustained virological response (SVR) rate >95…

Directacting antiviral agents for hepatitis C virus‐mixed cryoglobulinaemia: dissociated virological and haematological responses

G Pozzato, C Mazzaro, M Artemova… - British Journal of …, 2020 - Wiley Online Library
… of an abnormal pattern of antigen expression and light chain … treated with IFN-free therapies,
therefore, a direct comparison is … In conclusion, our present study demonstrated that IFN-free …

Antiviral activity of type I, II, and III interferons counterbalances ACE2 inducibility and restricts SARS-CoV-2

I Busnadiego, S Fernbach, MO Pohl, U Karakus… - MBio, 2020 - Am Soc Microbiol
… found that beta interferon (IFN-β) strongly upregulated expression of canonical antiviral ISGs,
… III IFN, we were unable to detect ACE2 cell surface expression following treatment with this …