Interferon response in hepatitis C virus-infected hepatocytes: issues to consider in the era of direct-acting antivirals
… Herein, we review recent studies on types I and III IFN responses in … related to IFN responses
in the direct-acting antiviral era. … that HCV infections induced IFN-λ4 expression at both the …
in the direct-acting antiviral era. … that HCV infections induced IFN-λ4 expression at both the …
HCV cure with direct-acting antivirals improves liver and immunological markers in HIV/HCV-coinfected patients
Ó Brochado-Kith, I Martínez, J Berenguer… - Frontiers in …, 2021 - frontiersin.org
… production of inflammatory mediators and interferon-stimulated genes (… analyzed the gene
expression between groups by generalized linear models (GLM) for non-paired comparison …
expression between groups by generalized linear models (GLM) for non-paired comparison …
[HTML][HTML] Direct-acting antivirals for patients with chronic hepatitis C and hepatocellular carcinoma in Taiwan
CT Chi, CY Chen, CW Su, PY Chen, CJ Chu… - Journal of Microbiology …, 2021 - Elsevier
… from interferon (IFN)-based therapy to direct acting antivirals (DAAs). The effect of antiviral
… Continuous variables were expressed as mean with standard deviation and median with …
… Continuous variables were expressed as mean with standard deviation and median with …
The impact of direct-acting antivirals on overall mortality and tumoral recurrence in patients with hepatocellular carcinoma listed for liver transplantation: an …
A Gorgen, Z Galvin, AC Huang, C Vinaixa… - …, 2020 - journals.lww.com
… Results of the multivariate analysis were expressed as HR with 95% CI. A P < 0.05 (2-… )
patients had been treated with IFN, and 642 (73.4%) patients were antiviral naïve at the time of LT …
patients had been treated with IFN, and 642 (73.4%) patients were antiviral naïve at the time of LT …
Functional comparison of interferon‐α subtypes reveals potent hepatitis B virus suppression by a concerted action of interferon‐α and interferon‐γ signaling
… , we observed a positive correlation of the inhibitory effect of specific IFN-α subtypes on HBV
RNA and HBeAg expression levels with their binding affinity to IFNAR1, but not to IFNAR2 (…
RNA and HBeAg expression levels with their binding affinity to IFNAR1, but not to IFNAR2 (…
Directly acting antivirals for COVID-19: where do we stand?
… other products such as human immunoglobulin, interferons, carrimycin, bevacizumab, cobicistat,
… Disclaimer: All claims expressed in this article are solely those of the authors and do not …
… Disclaimer: All claims expressed in this article are solely those of the authors and do not …
IFN-λ1 displays various levels of antiviral activity in vitro in a select panel of RNA viruses
M Plotnikova, A Lozhkov, E Romanovskaya-Romanko… - Viruses, 2021 - mdpi.com
… Antiviral Effect against Influenza To study the potential antiviral effects of type III interferon, …
We have shown an increase in SOCS-1 expression in response to both IVA infection and IFN-…
We have shown an increase in SOCS-1 expression in response to both IVA infection and IFN-…
Hepatocellular carcinoma risk according to regimens for eradication of hepatitis C virus; interferon or direct acting antivirals
… Simple Summary Owing to pegylated interferon (PegIFN)-free direct-acting antivirals (DAAs)
against chronic hepatitis C virus infection, a sustained virological response (SVR) rate >95…
against chronic hepatitis C virus infection, a sustained virological response (SVR) rate >95…
Direct‐acting antiviral agents for hepatitis C virus‐mixed cryoglobulinaemia: dissociated virological and haematological responses
G Pozzato, C Mazzaro, M Artemova… - British Journal of …, 2020 - Wiley Online Library
… of an abnormal pattern of antigen expression and light chain … treated with IFN-free therapies,
therefore, a direct comparison is … In conclusion, our present study demonstrated that IFN-free …
therefore, a direct comparison is … In conclusion, our present study demonstrated that IFN-free …
Antiviral activity of type I, II, and III interferons counterbalances ACE2 inducibility and restricts SARS-CoV-2
I Busnadiego, S Fernbach, MO Pohl, U Karakus… - MBio, 2020 - Am Soc Microbiol
… found that beta interferon (IFN-β) strongly upregulated expression of canonical antiviral ISGs,
… III IFN, we were unable to detect ACE2 cell surface expression following treatment with this …
… III IFN, we were unable to detect ACE2 cell surface expression following treatment with this …